The objective of the present study was to formulate and optimize tinidazolemicrogel. To achieve these objective fourteen formulations of microgel were prepared by emulsion solvent evaporation method using Eudragit polymer. A 32 factorial design was employed in formulating the microgel with concentration of surfactant (A) and stirring speed (B) as independent variables. Percent drug release was considered as dependent variable. The effect of drug-polymer concentration, surfactant concentration, cross-linking agent and stirring speed were evaluated with respect to entrapment efSficiency, particle size, surface characteristics, micromeritic properties, DSC study and in vitro drug release studies. The particle size and entrapment efficiency were found to be varied by changing various formulation parameters like surfactant concentration and stirring speed etc. IR study confirmed the drug-polymer compatibility and scanning electron microscopy indicates that the microgel have the rough and porous surface due to arising as a trace of solvent evaporation during the process. The release profile of tinidazole from Eudragitmicrogel was pH dependent. In acidic medium, the release rate was much slower; however, the drug was released quickly at pH 7.4. It is concluded from the present investigation that Eudragitmicrogel are promising as a carrier for targeted delivery of tinidazole.
Cite this article:
Pooja Yadav, Sunil Shah, Chandra Kishore Tyagi. Formulation and Evaluation of Tinidazole Microgel for Skin Delivery. Research Journal of Topical and Cosmetic Sciences. 2021; 12(1):43-0. doi: 10.52711/2321-5844.2021.00007
Pooja Yadav, Sunil Shah, Chandra Kishore Tyagi. Formulation and Evaluation of Tinidazole Microgel for Skin Delivery. Research Journal of Topical and Cosmetic Sciences. 2021; 12(1):43-0. doi: 10.52711/2321-5844.2021.00007 Available on: https://rjtcsonline.com/AbstractView.aspx?PID=2021-12-1-7
1. Chen, H., Chang, X., Weng, T., Zhao, X., Gao, Z., Yang, Y., Xu, H., Yang, X. 2004. A study of microemulsion systems for transdermal delivery of triptolide. J. Control. Rel. 98, 427-436.
2. Friend, D.R., Catz, P., Heller, J., Okagaki, M. 1989. Transdermal delivery of levonorgestrel: Preparation of devices and evaluation in vitro. Pharm. Res. 6, 938-944.
3. Barry, B.W 1991. The LPP theory of skin penetration enhancement. In: In Vitro Percutaneous Absorption: Principles, Fundamentals and Applications. Bronaugh, R.L.and Maibach, H.I. (eds.). CRC press, Orlando, FL, pp 165-185.
4. Sasaki, H., Kojima, M., Mori, Y., et al 1990. Enahaning effect of pyrolidone derivative on transdermal drug delivery: Effect of enhancer Int.J.Pharm.60,177-183.
5. Loth.H.1991.Vehicular influence on transdermal drug penetration. Int. J. Pharm. 68,1-10.
6. Nannapieri, E.; carelli, V.; Dicolo, G.; Giorgi, I. and Serafini, M.F.; “Vehicle influence on the permeation of highly lipophilic molecule. An in vitro technique to evaluate skin-vehicle interactions”. Int. J. Cosmet. Sci., 12, 21-31 (1990).
7. Hilton, J., Woolen et al 1994. Vehicles effect on in vitro percutaneous absorption through rat and human skin. Pharm. Res. 11, 1396-1400.
8. Kreilgaard, M. 2002. Influence of microemulsions on cutaneous drug delivery. Adv. Drug. Del. Rev. 54 (suppl.1), S77-S98.
9. Lawrence, M. J., Rees, G.D. (2000). Microemulsion based media as novel drug delivery systems. Adv. Drug Del.Rev. 45, 89-121.
10. Ktistis, G., Niopas, I. 1998. A study on the in-vitro percutaneous absorption of propranolol from disperse systems. J. Pharm. Pharmacol. 50(4), 413-418.
11. Elena, P., Paola, S., Maria,R.G. 2001. Transdermal permeation of apomorphine through hairless mouse skin. Int. J. Pharm. 226(1-2), 47-51.
12. Claudia, V., Katharina, S. 2004. Influence of carrageenan on the rheology and skin permeation of microemulsion formulation. J. Control. Rel. 95, 257-265.
13. Jessy, S., Srinivas, M.R. 2004. Microemulsion as drug delivery systems. Pharma Times. 36, 17-23.
14. Physician’s desk reference Edition – 56, 3275 – 3279 (2002).
15. Clark’s analysis of drugs and poison, (2005)