ABSTRACT:
Acne, common skin disorder in which follicles becomes blocked with sebum, dead skin cells and bacteria that causing skin redness and inflammation. Extract of plant parts were extracted by hot soxhlet extraction process using hydroalcoholic sovent (50:50). Dried extracts of Azadirachta indica leaves and Nigella sativa Seeds, Aloe barbadensis leaves pulp and essential oil of Melaleuca alternifolia were incorporated into gel base contains polymer carbopol (Grade 934 or 940) and formulated into gel. The gel was evaluated significant antibacterial property of Polyherbal gel formulation using Muller-Hinton agar plates against Staphylococcus aureus and Staphylococcus epidermidis while Reinforced Clostridial agar plate was prepared for evaluating antimicrobial activity against bacteria Propionibacterium acnes. Different physicochemical properties include color, appearance, consistency, washability, pH, spreadability, extrudability, viscosity, homogeneity etc. The prepared formulations did not show any phase separation it was stable and gel did not showed any irritation over skin. The result concluded that the developed 10% Polyherbal gel formulations (AgF1 to AgF10) are appropriate formulations and all formulations showed significant zone of inhibition against acne causing bacteria’s.
Cite this article:
Shivang Tripathi, Vishal Gupta. Formulation Development and evaluation for anti-acne activity of polyherbal gel. Research Journal of Topical and Cosmetic Sciences. 2025; 16(1):1-2. doi: 10.52711/2321-5844.2025.00002
Cite(Electronic):
Shivang Tripathi, Vishal Gupta. Formulation Development and evaluation for anti-acne activity of polyherbal gel. Research Journal of Topical and Cosmetic Sciences. 2025; 16(1):1-2. doi: 10.52711/2321-5844.2025.00002 Available on: https://rjtcsonline.com/AbstractView.aspx?PID=2025-16-1-2
REFERENCES:
1. Chandrasekar R. and Kumar G.S. Formulation
and Evaluation of a Polyherbal anti-acne gel. Research Journal of
Topical and Cosmetic Sciences. 2020; 11(1): 5-11.
2. Chellathurai B.J. et, al. Development of a Polyherbal Topical Gel for the Treatment of Acne. Gels. 2023; 9(163): 1-14.
3.
Nalla Priyanka, P. Brahmeswari, G. Raveendra Babu, M. Sowjanya, M.
Ramayyappa. Evaluation of Anti-bacterial and Anti-inflammatory
Activities of Ethanolic Extract of Hibiscus hirtus Linn. Leaves. Asian
Journal of Pharmaceutical Research. 2022; 12(1): 5-10.
4. Sowmya
K.V. et, al. Formulation and evaluation of poly-herbal face wash gel.
World Journal of Pharmacy and Pharmaceutical Sciences. 2015; 4(6):
585-588.
5. Sonali Syal, Vinay Pandit, M. S Ashawat. Traditional
Herbs to treat Acne Vulgaris. Asian J. Pharm. Res. 2020; 10(3): 195-201.
6.
Bilal M. et, al. Formulation of Anti-acne Extract Aloe vera in Hibiting
The Activity of Propionibacterium acnes. International Journal of
Science and Environment. 2023; 241-248.
7. Ross and Wilson. Anatomy and Physiology in Health and Illness. Elsevier. 2018; 13: 404.
8. Joseph T.D. et. al. Pharmacotherapy. A Pathophysiologic Approach. The McGraw-Hill Companies. 2008; 7: 1591-1592.
9. Mohit S.A. et al. Antimicrobial activity of leaves extracts of jotropha curcas. Asian J.pharm.Res. 2018; 8(1): 17-20.
10.
Tan JKL, et, al. Evaluation of essential clinical components and
features of current acne global grading scales. J Am Acad Dermatol.
2013; 69(5): 754–761.
11. Kikwai L. et, al. In vitro and in vivo
evaluation of topical formulations of spantide II. AAPS Pharm. Sci.
Tech. 2005; 6(4): 62-72.
12. S.K. Purohit, R. Solanki, R. Soni, V.
Mathur. Evaluation of Wound Healing Activity of Ethanolic Extract of
Azadirachta indica Leaves in Male Albino Rats. Asian J. Pharm. Tech.
2013; 3(2): 73-75.
13. Lekshmy M. et, al. Formulation and
Antimicrobial Evaluation of a Novel Anti acne herbal Hydrogel.
International Journal of Ayurveda and Pharma Research. 2022; 10(11):
23-26.
14. Pawłowicz K. et, al. Towards the Preparation of a
Hydrogel from Lyophilisates of the Aloe arborescens Aqueous Extract.
Pharmaceutics. 2022; 14(1489): 1-16.
15. Bhatia V. and Joyasar A.
Development of Polyherbal anti acne gel formulation. Journal of
Pharmacognosy and Phytochemistry. 2020; 9(2): 248-256.
16. Kajal
L.J. et, al. Preparation and Evaluation of Anti acne Herbal Gel.
European Journal of Biomedical and Pharmaceutical Sciences. 2017; 4(10):
578-581.
17. Kriti Sethi, Nayyar Parvez. Preliminary
Phytochemical Characterization and Micromeritic Properties evaluation of
Azadirachta indica and Syzygium aromaticum Powder. Asian J. Pharm. Res.
2019; 9(1): 22-26.
18. Borse V.A. et, al. Formulation and
Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil
and Tea Tree oil. International Journal of Pharmaceutical Education and
Research. 2020; 54(1): 206-212.
19. Dange V.N. et, al.
Formulation and Evaluation of Herbal Gel containing Lantana Camara for
Management of Acne Vulgaris. Journal of University of Shanghai for
Science and Technology. 2020; 22(11): 799-809.
20. Sanket. J.
Kapse, Nishigandha. D. Naikawadi, Mayuri. C. More, Prakash. D. Jadhav,
Vivekkumar Redasani. A overview on Pharmaceutical Application of Tree
Tea Oil. Research Journal of Pharmacognosy and Phytochemistry. 2024;
16(2): 125-9.
21. Neglo D. et, al. Antibiofilm Activity of
Azadirachta indica and Catharanthus roseus and their Synergistic Effects
in Combination with Antimicrobial Agents against Fluconazole-Resistant
Candida albicans strains and MRSA. Evidence Based Complementary and
Alternative Medicine. 2022; 1-13.
22. Mate A. et, al. Formulation
and Evaluation of Polyherbal Gel for the Management of Acne.
International Journal of Current Research and Review. 2020; 13(04):
117-122.
23. Madkholkar S. and Jagtap V. TO study in-vitro
antimicrobial activity of Polyherbal handwash formulation. Asian Journal
of Pharmacy and Technology. 2022; 12(3):237-1.
24. Preeti Tiwari.
Antimicrobial Activity of Amritarishta Prepared by Traditional and
Modern Methods. Asian J. Pharm. Res. 2014; 4(2): 114-116.
25.
Keerti Shrivastava, Sherendra Sahu, Skand K. Mishra, Kantishree De. In
vitro Antimicrobial Activity and Phytochemical Screening of Syzygium
aromaticum. Asian J. Res. Pharm. Sci. 2014; 4(1): 12-15.
26. R.
Malathi, A. Cholarajan, K. Karpagam, K.R. Jaya, P. Muthukumaran.
Antimicrobial Studies on Selected Medicinal Plants (Coleus amboinicus,
Phyla nodiflora and Vitex negundo). Asian J. Pharm. Tech. 2011; 1(2):
53-55.