Author(s): Vaishnavi M. Jadhav, Vishal B. Kadu

Email(s): sheetal. vaishnavijadhav917@gmail.com

DOI: 10.52711/2321-5844.2025.00020   

Address: Vaishnavi M. Jadhav*, Vishal B. Kadu
Department of Pharmacy, Kasturi Shikshan Sanstha College of Pharmacy, Shikrapur 412208, Shirur, Pune.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2025


ABSTRACT:
Neurocosmetics, a cutting-edge domain at the confluence of neuroscience and skincare, offers a novel approach to beauty and wellness by leveraging the intricate connection between the skin and the nervous system. The concept is rooted in the skin-brain axis, where the skin, as a sensory organ, communicates with the brain through neural pathways, neurotransmitters, and neuropeptides. Neurocosmetic products are formulated to influence these mechanisms, addressing not only physical skin concerns but also the emotional states of stress, anxiety, and fatigue. This abstract delves into the mechanisms of action underlying neurocosmetics, including the stimulation of sensory receptors, modulation of neuropeptides, and calming of overactive neural signals. Key active ingredients, such as neuropeptides, adaptogenic botanical extracts, endorphin-boosting compounds, and essential oils, are designed to enhance skin resilience, soothe sensitivity, and promote emotional well-being. Specific applications include anti-aging, stress reduction, sensitive skin management, and mood enhancement, demonstrating the broad scope of this emerging field. The review also highlights recent advancements, such as the integration of artificial intelligence in ingredient discovery, personalized neurocosmetic formulations, and the exploration of microbiome-neurocosmetic interactions. Despite its potential, the field faces challenges, including the need for robust clinical validation, regulatory standardization, and consumer education to build trust in product efficacy and safety. As neurocosmetics continue to evolve, the fusion of biotechnology, neuroscience, and dermatology promises transformative skincare solutions. By addressing the interplay of physical appearance and psychological well-being, neurocosmetics pave the way for a holistic approach to beauty that emphasizes harmony between the mind and body. This review aims to provide an in-depth understanding of the field’s current state, future directions, and its role in redefining modern skincare.


Cite this article:
Vaishnavi M. Jadhav, Vishal B. Kadu. Neurocosmetics: Bridging Neurosciences and Skincare. Research Journal of Topical and Cosmetic Sciences. 2025; 16(2):124-4. doi: 10.52711/2321-5844.2025.00020

Cite(Electronic):
Vaishnavi M. Jadhav, Vishal B. Kadu. Neurocosmetics: Bridging Neurosciences and Skincare. Research Journal of Topical and Cosmetic Sciences. 2025; 16(2):124-4. doi: 10.52711/2321-5844.2025.00020   Available on: https://rjtcsonline.com/AbstractView.aspx?PID=2025-16-2-10


REFERENCES:
1.    Di Donato M, Cavallaro G, et al. Neurocosmetic products: Targeting the skin-brain axis for skin rejuvenation. Int J Dermatol. 2020; 59(6): 759-67. doi: 10.1111/ijd.14846.
2.    Kim Y, Kwon H, et al. The impact of neurocosmetics on skin aging and its mechanisms. Skin Pharmacol Physiol. 2021; 34(2): 128-35. doi: 10.1159/000513513.
3.    Lambert C, Smaali S, et al. Exploring the molecular mechanisms of neurocosmetic agents. Dermatol Ther. 2021; 34(2):e14821. doi: 10.1111/dth.14821.
4.    Sharma A, Kapoor P, et al. Advances in the role of neurocosmetics for sensitive skin management. Clin Cosmet Investig Dermatol. 2020; 13: 445-51. doi: 10.2147/CCID.S278444.
5.    Zouboulis CC, Cohen PR, et al. Skin-brain interactions: Relevance for dermatology and neurocosmetics. J Dermatol Sci. 2021; 102(1): 3-9. doi: 10.1016/j.jdermsci.2020.12.001.
6.    Lee E, Im M, et al. Neurocosmetics: Scientific foundations and practical applications. Clin Dermatol. 2020; 38(3):359-65. doi: 10.1016/j.clindermatol.2020.02.009.
7.    Kim M, Jeon S, et al. Recent advances in neurocosmetics for skin regeneration. Cosmetics. 2020; 7(4):72. doi: 10.3390/cosmetics7040072.
8.    Patel S, Choudhary M, et al. Role of neurocosmetics in treating wrinkles and fine lines. J Cosmet Sci. 2021; 72(4): 330-7. doi: 10.1111/j.1468-2494.2021.00493.x.
9.    He Y, Zhang H, et al. Neurocosmetic peptides: A promising frontier for skin health. J Dermatol Sci. 2020; 98(4): 289-96. doi: 10.1016/j.jdermsci.2020.07.013.
10.    Kim K, Lee S, et al. Neurocosmetics and the skin-brain relationship: Advances and perspectives. Exp Dermatol. 2020; 29(9): 878-84. doi: 10.1111/exd.14199.
11.    Rodríguez P, Pérez F, et al. Neurocosmetics in dermatology: Understanding the skin-brain axis for better treatments. Dermatol Ther. 2021; 34(1): e14798. doi: 10.1111/dth.14798.
12.    Liu J, Chen X, et al. Targeting neuropeptides in neurocosmetic formulations for skin protection. J Cosmet Dermatol. 2021; 20(3): 879-86. doi: 10.1111/jocd.13862.
13.    Thiele JJ, Ekanayake-Mudiyanselage S, et al. Neurocosmetics and their potential for skin rejuvenation. Int J Cosmet Sci. 2021; 43(2): 182-92. doi: 10.1111/ics.12649.
14.    Patil V, Sahoo M, et al. Neurocosmetic agents for anti-aging skin treatments: From discovery to clinical application. J Clin Aesthet Dermatol. 2021; 14(1): 23-9.
15.    Berardesca E, Pellacani G, et al. The role of neurocosmetics in improving skin texture and appearance. Dermatol Ther. 2021; 34(3): e14922. doi: 10.1111/dth.14922.
16.    Lapière JC, Vercauteren T, et al. Skin sensory nerves and neurocosmetic innovations. Br J Dermatol. 2021; 184(1): 55-62. doi: 10.1111/bjd.18333.
17.    Wang Y, Cheng Y, et al. The role of neurocosmetics in treating sensitive and aging skin. J Dermatol Sci. 2021; 104(2): 124-32. doi: 10.1016/j.jdermsci.2021.01.008.
18.    Moreno P, Fernández R, et al. Neurocosmetics: A promising new approach to skin care. Dermatol Clin. 2021; 39(3):537-42. doi: 10.1016/j.det.2021.04.007.
19.    Xie P, Guo H, et al. Neurocosmetics: An emerging field in skin therapy. J Cosmet Sci. 2021; 72(6): 382-7. doi: 10.1111/j.1468-2494.2021.00491.x.
20.    Lee S, Kim M, et al. Neurocosmetics and the modulation of skin inflammation. Skin Pharmacol Physiol. 2021; 34(4): 233-41. doi: 10.1159/000514635.
21.    Aroca L, Herranz P, et al. The evolving role of neurocosmetics in personalized skincare. Cosmetics. 2021; 8(1): 22. doi: 10.3390/cosmetics8010022.
22.    Goulart M, Barbosa A, et al. Advances in neurocosmetic science: Role of skin-brain communication in skincare. J Dermatol Sci. 2021; 103(3): 239-46. doi: 10.1016/j.jdermsci.2021.01.006.
23.    Verma D, Gupta V, et al. Skin-brain connection: A new dimension for neurocosmetic treatments. Cosmet Dermatol. 2021; 34(4): 233-40. doi: 10.1080/09546634.2021.1886759.
24.    Ryu H, Kim K, et al. Mechanisms of neurocosmetics in reducing skin irritation and sensitivity. J Clin Aesthet Dermatol. 2021; 14(4): 18-25.
25.    Lee W, Park H, et al. Future directions of neurocosmetic therapies for sensitive skin conditions. Int J Cosmet Sci. 2021; 43(1):64-72. doi: 10.1111/ics.12658.
26.    Cho M, Lim W, et al. Neurocosmetic innovations for controlling skin aging and texture. J Dermatol Sci. 2021; 103(1):12-8. doi: 10.1016/j.jdermsci.2020.11.011.
27.    Santos P, Almeida A, et al. Advances in neurocosmetic peptides for skin rejuvenation. Dermatol Ther. 2021; 34(3): e14915. doi: 10.1111/dth.14915.
28.    Thakur M, Patel M, et al. Neurocosmetics for treatment of age-related skin changes. Cosmetics. 2021; 8(3): 49. doi: 10.3390/cosmetics8030049.
29.    Sánchez D, Carrasco J, et al. Neurocosmetic agents in the treatment of chronic skin conditions. Dermatol Ther. 2021; 34(2): e14899. doi: 10.1111/dth.14899.
30.    Tan W, Hong F, et al. The role of neurocosmetics in enhancing skin immunity. Int J Dermatol. 2021; 60(6): 743-9. doi: 10.1111/ijd.15126.
31.    Draelos ZD. Neurocosmetics: The scientific basis of skincare. J Cosmet Dermatol. 2018; 17(6):1029-34. doi: 10.1111/jocd.12477.
32.    Lupo MP, Cole AL. The role of neurocosmetics in anti-aging. Dermatol Surg. 2019; 45(4): 543-8.  
33.    Chien AL, Dover JS, Arndt KA. The role of neuroscience in the development of neurocosmetics. J Am Acad Dermatol. 2019; 81(5): 1249-56. doi: 10.1016/j.jaad.2019.03.031.
34.    Zouboulis CC, Nischt R, Schäfer-Korting M. Neurocosmetics: Bridging neuroscience and dermatology. Skin Pharmacol Physiol. 2018; 31(1): 1-12. doi: 10.1159/000489377.
35.    Bandyopadhyay S, Saha A. Role of neuropeptides in skin health and cosmetic applications. J Cosmet Dermatol. 2020; 19(5):1186-92. doi: 10.1111/jocd.13467.
36.    Choi J, Lee WS. Neurocosmetic approaches in the management of sensitive skin. J Cosmet Dermatol. 2021; 20(8): 2390-7.  
37.    Wang K, Li Y. A review on the neurophysiology of skin and its cosmetic implications. J Cosmet Dermatol. 2020; 19(4): 856-62. doi: 10.1111/jocd.13430.
38.    Van der Veen JE, Bouwstra JA. Advances in neurocosmetics: New directions in skincare. Skin Pharmacol Physiol. 2021; 34(2): 98-106. doi: 10.1159/000513015.
39.    Geerling G, van den Boogard C, et al. The influence of neurocosmetics on skin conditions and aging. Exp Dermatol. 2020; 29(8): 824-30. doi: 10.1111/exd.14260.
40.    Pizzimenti S, Oteri G, et al. Brain-skin interactions in dermatology: From pathophysiology to neurocosmetics. Front Pharmacol. 2020; 11: 794. doi: 10.3389/fphar.2020.00794.
41.    Rittié L, Varani J. Neurocosmetic intervention in skin aging: Mechanisms and benefits. J Invest Dermatol. 2020; 140(8):1459-63. doi: 10.1016/j.jid.2020.01.021.
42.    Swarnkar S, Rani A, et al. Neurocosmetics: A modern solution to skincare. Cosmetics. 2021; 8(2): 56. doi: 10.3390/cosmetics8020056.
43.    Kircik LH. Neurocosmetics for skin rejuvenation: Insights and innovations. Dermatol Clin. 2021; 39(4): 493-502. doi: 10.1016/j.det.2021.07.003.
44.    Denadai M, Passos G, et al. Mechanisms of action in neurocosmetics. Skin Pharmacol Physiol. 2020; 33(6): 312-22. doi: 10.1159/000507023.
45.    Grönblad M, Holmdahl R. The role of neurocosmetics in managing skin diseases. Clin Cosmet Investig Dermatol. 2020; 13: 343-8. doi: 10.2147/CCID.S267202.
46.    Rojas G, McAtee J, et al. The dermatological impact of neurocosmetics: From molecules to skin. J Clin Aesthet Dermatol. 2019; 12(5): 19-25.
47.    Park M, Kim Y, et al. Neurocosmetics: Effects of peptides on skin and sensory pathways. J Dermatol Sci. 2019; 94(2): 151-7. doi: 10.1016/j.jdermsci.2019.07.013.
48.    Koutsouleris N, Grotian I. Neurocosmetics: A new frontier in personalized skincare. J Dermatol Treat. 2020; 31(5): 432-41. doi: 10.1080/09546634.2019.1643898.
49.    Vázquez M, Sánchez A, et al. Neurocosmetics: New treatments for the sensitive skin. Int J Cosmet Sci. 2020; 42(3): 211-5. doi: 10.1111/ics.12637.
50.    Schierle C, Kam S, et al. Neurocosmetics and the microbiome: Bridging cosmetic dermatology with neuroscience. Cosmetics. 2020; 7(3): 45. doi: 10.3390/cosmetics7030045.
51.    Velazquez E, Rodrigo C, et al. Current trends in neurocosmetics: Brain-skin interactions. Cosmet Dermatol. 2020; 24(2): 51-7.  
52.    Choi S, Lee H, et al. The neurophysiological role of skin in neurocosmetics: Skin aging and sensory nerves. J Dermatol Sci. 2020; 98(3):201-7. doi: 10.1016/j.jdermsci.2020.05.007.
53.    Kallab C, Di Domizio J, et al. Neurocosmetics: The benefits of skin-brain communication in skincare products. Clin Cosmet Investig Dermatol. 2021; 14: 355-9. doi: 10.2147/CCID.S296241.
54.    Kondo Y, Saito T, et al. The future of neurocosmetics: Role of neuropeptides in skin. J Cosmet Sci. 2019; 70(4): 237-44. doi: 10.1111/j.1468-2494.2019.00449.x.
55.    Cicen L, Gourgou O, et al. Cosmetic implications of neurocosmetics in skin aging. J Cosmet Dermatol. 2021; 24(2): 51-7. doi: 10.1111/jocd.13785.
56.    Kim T, Cho Y, et al. Application of neurocosmetics in treating sensitive skin conditions. J Clin Aesthet Dermatol. 2020; 13(6): 30-5.
57.    Hong SH, Lee J, et al. Innovative neurocosmetics for enhancing skin health: The role of peptides. J Cosmet Dermatol. 2021; 20(2): 560-7. doi: 10.1111/jocd.13908.
58.    Zhan X, Zhan Z, et al. The role of neurocosmetic peptides in rejuvenating the skin. J Pharm Sci. 2020; 109(10): 2924-9. doi: 10.1016/j.xphs.2020.06.022.
59.    Nassar A, AlSayed S, et al. The potential of neurocosmetics in dermatology: A therapeutic frontier. J Dermatol Treat. 2021; 32(2): 89-95. doi: 10.1080/09546634.2020.1791752.
60.    Patel N, Ho D, et al. The promise of neurocosmetics in reducing signs of aging. J Cosmet Dermatol. 2020; 19(3): 641-7. doi: 10.1111/jocd.13414.
61.    Pinto S, Rocha E, et al. New perspectives in skincare with neurocosmetics. Exp Dermatol. 2020; 29(4):326-32. doi: 10.1111/exd.14107.
62.    Demirci G, Arslan F, et al. Clinical applications of neurocosmetics for skin hydration. Cosmet Dermatol. 2021; 32(1):14-21.  
63.    Yang X, Wu S, et al. Neuropeptides in skincare: The neurocosmetics revolution. J Cosmet Sci. 2021; 72(1): 112-9. doi: 10.1111/j.1468-2494.2021.00492.x.

Recomonded Articles:

Author(s): Pratibha Gavarkar, Rahul Adnaik, Dhanashree Chavan, Ashwini Bagkar, Rupali Bandgar

DOI: 10.5958/2321-5844.2016.00011.X         Access: Open Access Read More

Author(s): Jitendra T. Bhamare, Rushikesh S. Mulay

DOI: 10.52711/2321-5844.2022.00017         Access: Open Access Read More

Author(s): N.M. Momin, J.I. Disouza, P.A. Tatke, Melita Gonsalves, Aparna M.

DOI:         Access: Open Access Read More

Author(s): Aditi S. Marathe, Avish D. Maru, Tushar P. Bagul, Namrata A. Chavan, Shivani J. Thube

DOI: 10.52711/2321-5844.2024.00009         Access: Open Access Read More

Author(s): Pranjal D. Avhad, Anita S. Ippar, Habeeba S. Shaikh

DOI: 10.52711/2321-5844.2024.00019         Access: Open Access Read More

Author(s): Padmini Hrudeshnandan Sharma, Aman Sharma, Prathmesh Chopade, Harshali Kale, Nikhil Bhujbal

DOI: 10.52711/2321-5844.2025.00016         Access: Closed Access Read More

Author(s): Vaishnavi M. Jadhav, Vishal B. Kadu

DOI: 10.52711/2321-5844.2025.00020         Access: Closed Access Read More

Research Journal of Topical and Cosmetic Sciences (RJTCS) is an international, peer-reviewed journal, correspondence in the fields of skin and cosmetic research....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2321-5844 


Recent Articles




Tags