Author(s):
Shital P Khavare, Sakshi D Danawade, Vrushali G Khot
Email(s):
shitalkhavare2498@gmail.com
DOI:
10.52711/2321-5844.2025.00015 
Address:
Shital P Khavare1, Sakshi D Danawade2, Vrushali G Khot3
1Lecturer, KLE College of Pharmacy, Akkol Road, Nipani.
2,3KLE College of Pharmacy, Akkol Road, Nipani.
*Corresponding Author
Published In:
Volume - 16,
Issue - 2,
Year - 2025
ABSTRACT:
Background: In recent years, due to globalization and industrialization there have been Unhygienic conditions in undeveloped countries. Pollution in developing and developed countries has resulted in a pathetic increase in the number of life-threatening infections. Due to these various reasons, there is an increase in various species of fungal infections. Ketoconazole is a potent antifungal drug, according to BCS, Ketoconazole is categorized under class-2, which has high permeability and low solubility. Thus, it suffers from a problem in formulation development with poor bioavailability and low aqueous solubility. Objective: The objective of the present study was to formulate and evaluate ketoconazole gel for topical use. Methodology: The solubility study was carried out to identify and characterize the procured drug sample and excipients. A preliminary solubility study was performed. Eucalyptus oil, Poloxamer, Propylene Glycol, Potassium Sorbate, Lecithin, isopropyl Myristate, castor oil and Paraffin oil are used for the formulation of a gel. Results: The procured drug sample was confirmed to be Ketoconazole and was in its pure form. The formulation was formulated using a surfactant and oils selected from the solubility studies of drug in various oil and surfactants. This study concludes that the pH of the formulation was found to be 6.6 – 7.8. and viscosity of the formulation was obtained at 3883 cP. Conclusion: The present study demonstrated a systematic approach for the development of ketoconazole gel which can be very useful for the topical delivery of many emerging hydrophobic drugs with good therapeutic potential.
Cite this article:
Shital P Khavare, Sakshi D Danawade, Vrushali G Khot. Formulation and Evaluation of Ketoconazole Gel for Topical Use. Research Journal of Topical and Cosmetic Sciences. 2025; 16(2):91-6. doi: 10.52711/2321-5844.2025.00015
Cite(Electronic):
Shital P Khavare, Sakshi D Danawade, Vrushali G Khot. Formulation and Evaluation of Ketoconazole Gel for Topical Use. Research Journal of Topical and Cosmetic Sciences. 2025; 16(2):91-6. doi: 10.52711/2321-5844.2025.00015 Available on: https://rjtcsonline.com/AbstractView.aspx?PID=2025-16-2-5
REFERENCES:
1. Patel MR, Patel RB, Parikh JR, Solanki AB, Patel BG. Investigating effect of microemulsion components: in vitro permeation of ketoconazole. Pharmaceutical development and technology. 2011; 3: 250-8.
2. Kaur IP, Kakkar S. Topical delivery of antifungal agents. Expert opinion on drug delivery. 2010; 11:1303-27.
3. Choi FD, Juhasz ML, Mesinkovska NA. Topical ketoconazole: a systematic review of current dermatological applications and future developments. Journal of Dermatological Treatment. 2019.
4. Gupta AK, Daigle D, Foley KA. Drug safety assessment of oral formulations of ketoconazole. Expert opinion on drug safety. 2015; 2:325-34.
5. Kakkar S, Kaur IP. Spanlastics—A novel nano vesicular carrier system for ocular delivery. International journal of pharmaceutics. 2011; 413(1-2): 202-10.
6. Sadozai SK, Khan SA, Karim N, Becker D, Steinbrück N, Gier S, Baseer A, Breinig F, Kickelbick G, Schneider M. Ketoconazole-loaded PLGA nanoparticles and their synergism against Candida albicans when combined with silver nanoparticles. Journal of Drug Delivery Science and Technology. 2020; 56: 101574.
7. Chudasama A, Shah B, Patel V, Nivsarkar M, Vasu K, Shishoo C. Development of self-emulsifying drug delivery system of itraconazole for oral delivery: formulation and pharmacokinetic consideration. Journal of Pharmaceutical Investigation. 2015; 45(3): 271-83
8. Yadav H, Ramesh K, Islam M. Development and evaluation of Self micro emulsifying drug delivery system of Itraconazole. Am. J. PharmTech Res. 2017: 7(6); 126-136.
9. Wróblewska M, Szymańska E, Winnicka K. The influence of tea tree oil on antifungal activity and pharmaceutical characteristics of Pluronic® F-127 gel formulations with ketoconazole. International Journal of Molecular Sciences. 2021 Oct 20; 22(21): 11326.
10. Popovska O, Kavrakovski Z, Rafajlovska V. Development and validation of UV spectroscopic method for determination of ketoconazole in pharmaceutical formulations. Int J Pharm, 2014; 4: 95-101.