Author(s):
Sheetal S. Samant, Tanaya Keluskar, Shweta Sawant, Sarvesh Shinde, Shivani Hegishte, Saloni Kavitkar, Sushila Sawant, Vijay A. Jagtap
Email(s):
sheetal.samant99@gmail.com
DOI:
10.52711/2321-5844.2026.00025
Address:
Sheetal S. Samant1*, Tanaya Keluskar2, Shweta Sawant2, Sarvesh Shinde2, Shivani Hegishte2, Saloni Kavitkar2, Sushila Sawant2, Vijay A. Jagtap2
1Assistant Professor, Department of Pharmacognosy, Yashwantrao Bhonsale College of Pharmacy, Sawantwadi, Maharashtra, India.
2Yashwantrao Bhonsale College of Pharmacy, Sawantwadi, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 2,
Year - 2026
ABSTRACT:
Skin hyperpigmentation is a common issue in dermatology, and reversing it is a major concern for skin care professionals, especially since the majority of the global population has brown skin. Melanin, a pigment responsible for skin color, increases in amount, leading to hyperpigmentation. Treating hyperpigmentation disorders can be challenging and requires patience and knowledge of various therapies. Recently, new treatments have emerged, including hydroquinone and topical retinoids as first-line options. The use of conventional skin lightening agents is often limited by their potential to cause skin irritation. As a result, there is a growing interest in exploring natural compounds as safer and more tolerable alternatives. This summary aims to provide an overview of natural ingredients that have been investigated for their skin depigmenting properties.
Cite this article:
Sheetal S. Samant, Tanaya Keluskar, Shweta Sawant, Sarvesh Shinde, Shivani Hegishte, Saloni Kavitkar, Sushila Sawant, Vijay A. Jagtap. Unlocking the Power of Plants: Phytomedicines for the Treatment of Hyperpigmentation. Research Journal of Topical and Cosmetic Sciences. 2026; 17(2):165-4. doi: 10.52711/2321-5844.2026.00025
Cite(Electronic):
Sheetal S. Samant, Tanaya Keluskar, Shweta Sawant, Sarvesh Shinde, Shivani Hegishte, Saloni Kavitkar, Sushila Sawant, Vijay A. Jagtap. Unlocking the Power of Plants: Phytomedicines for the Treatment of Hyperpigmentation. Research Journal of Topical and Cosmetic Sciences. 2026; 17(2):165-4. doi: 10.52711/2321-5844.2026.00025 Available on: https://rjtcsonline.com/AbstractView.aspx?PID=2026-17-2-10
REFERENCES:
1. Shakya AK. Medicinal plants: Future source of new drugs. International Journal of Herbal Medicine. 2016; 4(4); 59-64.
2. Huang CF, Lin SS, Liao PH, Young SC, Yang CC. The immune pharmaceutical effects and mechanisms of herb medicine. Cellular and Molecular Immunology. Feb, 2008; 5(1); 23-31.
3. Upralkar S, Gadekar A, Kalangutkar P, Rane R, Morye R, Desai S, Tawade O, Samant SS, Jagtap VA. Ethnobotanical Survey of Medicinal Plants Commonly Used by Traditional Medicine Practitionersin Sindhudurg Region. India. International Journal of Ayurvedic Medicine. 2023; 14(1); 151-6.
4. Muragi A, Samant S, Patil MB. Formulation and Evaluation of Herbal Emulgel Loaded with Extractof Cedrus Deodara for its In-vitro Anti-Inflammatory Activity. International Journal of Ayurvedic Medicine. Oct 2022; 13(3); 749-53.
5. Rigopoulos D, Gregoriou S, Katsambas A. Hyperpigmentation and melasma. Journal of Cosmetic Dermatology. Sept, 2007; 6(3); 195-202.
6. Leyden JJ, Shergill B, Micali G, Downie J, Wallo W. Natural options for the management of hyperpigmentation. Journal of the European Academy of Dermatology and Venereology. Oct 2011; 25(10); 1140-5.
7. Schalka S. New data on hyperpigmentation disorders. Journal of the European Academy of Dermatology and Venereology. Sept, 2017; 31; 18-21.
8. Pandya AG, Guevara IL. Disorders of hyperpigmentation. Dermatologic Clinics. Jan 2000; 18(1); 91-8.
9. Qaiyyum IA, Nergis A. The therapeutic uses and pharmacopeal action of jirjeer (Eruca sativa): A review. CellMed. 2022; 12(2); 7-1.
10. Barillari J, Canistro D, Paolini M, Ferroni F, Pedulli GF, Iori R, Valgimigli L. Direct antioxidant activity of purified glucoerucin, the dietary secondary metabolite contained in rocket (Eruca sativa Mill.) seeds and sprouts. Journal of Agricultural and Food Chemistry. Apr 2005; 53(7); 2475-82.
11. Gulfraz M, Sadiq A, Tariq H, Imran M, Qureshi R, Zeenat A. Phytochemical analysis and antibacterial activity of Eruca sativa seed. Pak. J. Bot. Apr 2011; 43(2); 1351-9.
12. Kim HS. Anti-melanogenic effect of Eruca sativa extract. Korean Journal of Food Preservation. 2016; 23(1); 74-9.
13. Meziant L, Bachir-bey M, Bensouici C, Saci F, Boutiche M, Louaileche H. Assessment of inhibitory properties of flavonoid-rich fig (Ficus carica L.) peel extracts against tyrosinase, α-glucosidase, urease and cholinesterases enzymes, and relationship with antioxidant activity. European Journal of Integrative Medicine. Apr 2021; 43; 101272.
14. Bonamonte D, Foti C, Lionetti N, Rigano L, Angelini G. Photoallergic contact dermatitis to 8‐methoxypsoralen in Ficus carica. Contact Dermatitis. Jun 2010; 62(6); 343-8.
15. Mawa S, Husain K, Jantan I. Ficus carica L.(Moraceae): phytochemistry, traditional uses and biological activities. Evidence-Based Complementary and Alternative Medicine. Oct, 2013.
16. Russo E, Scicchitano F, Whalley BJ, Mazzitello C, Ciriaco M, Esposito S, Patanè M, Upton R, Pugliese M, Chimirri S, Mammì M. Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug–drug interactions. Phytotherapy Research. May, 2014; 28(5); 643-55.
17. Rabanal RM, Bonkanka CX, Hernández-Pérez M, Sanchez-Mateo CC. Analgesic and topical anti-inflammatory activity of Hypericum canariense L. and Hypericum glandulosum Ait. Journal of Ethnopharmacology. Jan 2005; 96(3); 591-6.
18. Worbs S, Köhler K, Pauly D, Avondet MA, Schaer M, Dorner MB, Dorner BG. Ricinus communis intoxications in human and veterinary medicine—a summary of real cases. Toxins. Oct 2011; 3(10); 1332-72.
19. Scarpa A, Guerci A. Various uses of the castor oil plant (Ricinus communis L.) a review. Journal of Ethnopharmacology. Mar 1982; 5(2); 117-37.
20. Valderramas AC, Moura SH, Couto M, Pasetto S, Chierice GO, Guimarães SA, de Paula Zurron AC. Antiinflammatory activity of Ricinus communis derived polymer. Brazilian Journal of Oral Sciences. 2008; 7(27); 1666-72.
21. Farag MA, Porzel A, Mahrous EA, El-Massry MM, Wessjohann LA. Integrated comparative metabolite profiling via MS and NMR techniques for Senna drug quality control analysis. Analytical and Bioanalytical Chemistry. Mar 2015; 407; 1937-49.
22. Singh H, Chahal P, Mishra A, Mishra AK. An up-to-date review on chemistry and biological activities of Senna occidentalis (L.) Link Family: Leguminosae. Advances in Traditional Medicine. Sept, 2020; 20; 263-78.
23. Chatatikun M, Chiabchalard A. Thai plants with high antioxidant levels, free radical scavenging activity, anti-tyrosinase and anti-collagenase activity. BMC Complementary and Alternative Medicine. Dec, 2017; 17(1); 1-9.
24. Raghav SK, Gupta B, Agrawal C, Goswami K, Das HR. Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells. Journal of ethnopharmacology. Mar, 2006; 104(1-2); 234-9.
25. Reddy DN, Al-Rajab AJ. Chemical composition, antibacterial and antifungal activities of Ruta graveolens L. volatile oils. Cogent Chemistry. Dec 2016; 2(1); 1220055.
26. Bruni R, Barreca D, Protti M, Brighenti V, Righetti L, Anceschi L, Mercolini L, Benvenuti S, Gattuso G, Pellati F. Botanical sources, chemistry, analysis, and biological activity of furanocoumarins of pharmaceutical interest. Molecules. June 2019; 24(11); 2163.
27. Karkouch I, Tabbene O, Gharbi D, Mlouka MA, Elkahoui S, Rihouey C, Coquet L, Cosette P, Jouenne T, Limam F. Antioxidant, antityrosinase and antibiofilm activities of synthesized peptides derived from Vicia faba protein hydrolysate: A powerful agents in cosmetic application. Industrial Crops and Products. Dec 2017; 109; 310-9.
28. Zibaee E, Amiri MS, Boghrati Z, Farhadi F, Ramezani M, Emami SA, Sahebkar A. Ethnomedicinal uses, phytochemistry and pharmacology of Dorema species (Apiaceae): a review. Journal of Pharmacopuncture. Sept 2020; 23(3); 91.
29. Funel N, Dini V, Janowska A, Loggini B, Minale M, Grieco F, Riccio S, Romanelli M. Triticum vulgare extract modulates protein-kinase b and matrix metalloproteinases 9 protein expression in bv-2 cells: Bioactivity on inflammatory pathway associated with molecular mechanism wound healing. Mediators of Inflammation. Feb 2020; 2020.
30. Tito A, Minale M, Riccio S, Grieco F, Colucci MG, Apone F. A Triticum vulgare extract exhibits regenerating activity during the wound healing process. Clinical, Cosmetic and Investigational Dermatology. Jan 2020; 21-30.
31. Gill BS, Mehra R, Navgeet, Kumar S. Vitex negundo and its medicinal value. Molecular Biology Reports. Dec 2018; 45(6); 2925-34.
32. Das S, Parveen S, Kundra CP, Pereira BM. Reproduction in male rats is vulnerable to treatmentwith the flavonoid‐rich seed extracts of Vitex negundo. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. Jan 2004; 18(1); 8-13.
33. Gryn-Rynko A, Bazylak G, Olszewska-Slonina D. New potential phytotherapeutics obtainedfrom white mulberry (Morus alba L.) leaves. Biomedicine and Pharmacotherapy. Dec 2016; 84; 628-36.
34. Butt MS, Nazir A, Sultan MT, Schroën K. Morus alba L. nature's functional tonic. Trends in Food Science and Technology. Oct 2008; 19(10); 505-12.
35. Upadhye M, Kuchekar M, Pujari R, Kadam S, Gunjal P. Muntingia calabura: A comprehensive review Journal of Pharmaceuticaland Biological Sciences. Jul 2021; 9(2); 81
36. Nur S, Nursamsiar N, Aswad M, Tumigolung AE, Yulianti R, Burhan A. Screening Bioactivityof Kersen Fruits (Muntingia calabura L.) as a Sunscreens Candidate. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal). Mar 2021; 7(1); 29-38.
37. Pang Y, Wang D, Fan Z, Chen X, Yu F, Hu X, Wang K, Yuan L. Blumea balsamifera—Aphytochemical and pharmacological review. Molecules. Jul 2014; 19(7); 9453-77.
38. Saewan N, Koysomboon S, Chantrapromma K. Anti-tyrosinase and anti-cancer activities offlavonoids from Blumea balsamifera DC. J Med Plants Res. Mar 2011; 5(6); 1018-25.
39. Naser W. Recent studies regarding the use of medicinal plant extracts as skin care photoprotective cosmeceuticals: A review. Pharm Online. 2020; 3; 151–165
40. Wang S, Zhang S, Wang S, Gao P, Dai L. A comprehensive review on Pueraria: Insights on its chemistry and medicinal value. Biomedicine and Pharmacotherapy. Nov 2020; 131; 110734.
41. Kim MJ, Shin SY, Song NR, Kim S, Sun SO, Park KM. Bioassay-guided characterization, antioxidant, anti-melanogenic and anti-photoaging activities of pueraria thunbergiana L. Leaf extracts in human epidermal keratinocytes (HaCaT) cells. Processes. Oct 2022; 10(10); 2156.
42. Deng J, Li J, Su M, Lin Z, Chen L, Yang P. A bHLH gene NnTT8 of Nelumbo nucifera regulates anthocyanin biosynthesis. Plant Physiology and Biochemistry. Jan 2021; 158; 518-23.
43. Morikawa T, Kitagawa N, Tanabe G, Ninomiya K, Okugawa S, Motai C, Kamei I, YoshikawaM, Lee IJ, Muraoka O. Quantitative determination of alkaloids in lotus flower (flower buds of Nelumbo nucifera) and their melanogenesis inhibitory activity. Molecules. Jul, 2016; 21(7); 930.
44. Sircar D, Dey G, Mitra A. A validated HPLC method for simultaneous determination of 2-hydroxy-4-methoxybenzaldehyde and 2-hydroxy-4-methoxybenzoic acid in root organs of Hemidesmus indicus. Chromatographia. Mar 2007; 65; 349-53.
45. Gupta R, Saxena R, Patidar A, Chourasiya Y, Malviya N. Review on anti-tyrosinase activity of some Indian medicinal plants and their phytoconstituents. Journal of Drug Delivery and Therapeutics. Oct 2020; 10(5-s); 199-204.
46. Garcia-Oliveira P, Barral M, Carpena M, Gullón P, Fraga-Corral M, Otero P, Prieto MA, Simal-GandaraJ.Traditional plants from Asteraceae family as potential candidates for functional food industry. Food and Function. 2021; 12(7); 2850-73.
47. Ceilley RI. Treatment of actinic purpura. The Journal of Clinical and Aesthetic Dermatology. Jun 2017; 10(6); 44.
48. BADAWY AM. Review article on Chemical constituents and Biological activity of Thymelaea hirsuta. Records ofPharmaceutical and Biomedical Sciences. Sep 2019; 3(2); 28-32.
49. Nadzira Hanif, Abdulkareem Mohammed Ahmed Al-Shami, Kamarul Ariffin Khalid, Hazrina Ab Hadi. Plant-based skin lightening agents: A review. The Journal of Phytopharmacology 2020; 9(1); 54-60
50. Waqas, M.K., Akhtar, N., Mustafa, R., Jamshaid, M., Khan, H.M. and Murtaza, G. Dermatological and cosmeceutical benefits of Glycin max (soybean) and its active components. Acta Pol Pharm. 2015; 72(1); 3-11.
51. A Adhikari, H. P. Devkota, A. Takano-, K. Masuda T. Nakane, P. Basnet, N. Skalko-Basnet. The School of Pharmaceutical and Biomedical Sciences, Pokhara University, Pokhara, PO Box 427, Pokhara, Nepal, –Medicinal Plant Garden and Department of Phytochemistry, Showa Pharmaceutical University, Machida, 194-8543
52. Amalina, N.D., Wahyuni, S., Suzery, M, Cahyono B. Citrus aurantium peels secondary metabolites prevents cell senescence on human fibroblasts cells by in vitro and bioinformatics studies. The Thai Journal of Pharmaceutical Sciences. 2022; 46(5); 570-578.
53. Cobzac, S., Moldovan, M., Olah, N.K, Bobos, L. and Surducan, E. Tannin extraction efficiency, from Rubus idaeus, Cydonia oblonga and Rumex acetosa, using different extraction techniques and spectrophotometric quantification. Seria F Chemia. 2005; 8; 55-59.
54. Pattarawan Rattanawiwatpong MD, Rungsima Wanitphakdeedecha MD. Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial. J Cosmet Dermatol. Mar 2020; 19(3); 671–676.
55. Gupta S, Walia A, Malan R. Phytochemistry and pharmacology of cedrus deodara: an overview. International Journal of Pharmaceutical sciences and research. 2011; 2(8); 2010.
56. Bisht, A., Jain, S., Misra, A., Dwivedi, J., Paliwal, S. and Sharma, S., 2021. Cedrus deodara (Roxb. ex D. Don) G. Don: A review of traditional use, phytochemical composition and pharmacology. Journal of Ethnopharmacology. 2021; 279; 114361
57. Liu-Smith F, Meyskens FL (2016) Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma. Mol Nutr Food Res 60(6): 1264–1274.
58. Halfidz, K.A., Puspitasari, N., Yanuar, A., Artha, Y. and Mun’im, A. HMG-CoA Reductase inhibitory activity of Gnetum gnemon seed extract and identification of potential inhibitors for lowering cholesterol level. Journal of Young Pharmacists. 2017; 9(4); 559.
59. B CC, P Haloi, IC Barua. Gnetum gnemon Linn.: a comprehensive review on its biological, pharmacological and pharmacognostical potentials. International Journal of Pharmacognosy and Phytochemical Research. 2015; 7(3); 531-539.
60. M.P. Germanò, F. Cacciola, P. Donato, P. Dugo, G. Certo, V. D’Angelo, L. Mondello, A. Rapisarda, Betula pendula leaves: Polyphenolic characterization and potential innovative use in skin whitening products. Fitoterapia. 2012; 83(5); 877-882.
61. Calliste CA, Trouillas P, Allais DP, Simon A, Duroux JL. Free radical scavenging activities measured by electron spin resonance spectroscopy and B16 cell antiproliferative behaviors of seven plants. J Agric Food Chem. 2001; 49(7); 3321-3327.
62. He, X., Fang, J., Huang, L., Wang, J. and Huang, X. Sophora flavescens Ait.: Traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicine. Journal of Ethnopharmacology. 2015; 172; 10-29.
63. Shin, D.H., Cha, Y.J., Joe, G.J., Yang, K.E., Jang, I.S., Kim, B.H. and Kim, J.M. Whitening effect of Sophora flavescens extract. Pharmaceutical Biology. 2013; 51(11); 1467 - 1476.
64. Chang, T.S. An updated review of tyrosinase inhibitors. International Journal of Molecular Sciences. 2009; 10(6); 2440- 2475.
65. Batiha, G.E.S, Shaheen, H.M., Elhawary, E.A., Mostafa, N.M., Eldahshan, O.A, Sabatier, J.M. Phytochemical constituents, folk medicinal uses, and biological activities of genus Angelica: A review. Molecules. 2022; 28(1); 267.
66. Ullah S, Shoaib R, Khan S. and Masood A. Phytochemicals; Targeted-Based Therapeutic Approaches for Pigmentation Disorders. Open Access Indonesian Journal of Medical Reviews. 2023; 3(2); 339-352.
67. Lee SY, Baek N, Nam TG. Natural, semisynthetic and synthetic tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016; 31(1); 1-13.
68. Wang, G.H., Chen, C.Y., Tsai, T.H., Chen, C.K., Cheng, C.Y., Huang, Y.H., Hsieh, M.C. and Chung Y.C. Evaluation of tyrosinase inhibitory and antioxidant activities of Angelica dahurica root extracts for four different probiotic bacteria fermentations. Joumal of Bioscience and Bioengineering. 2017; 123(6); 679-684.
69. Martínez Jorge, Nevado Ander, Suñén Ester, Gabriel Marta, Vélez-del-Burgo Ainara, Sánchez Patricia, Postigo Idoia.The Aspergillus niger Major Allergen (Asp n 3) DNA-Specific Sequence Is a Reliable Marker to Identify Early Fungal Contamination and Postharvest Damage in Mangifera indica Fruit Frontiers in Microbiology. 2021; 12
70. Ammar, H.A., Ezzat, S.M, Houseny, A.M. Improved production of kojic acid by mutagenesis of Aspergillus flavus HAk1 and Aspergillus oryzae HAk2 and their potential antioxidant activity. 3 Biotech. 2017; 7; 1-13.
71. Park, Yuna, et al. Decursin and Z-ligustilide in Angelica tenuissima root extract fermented by Aspergillus oryzae display anti-pigment activity in melanoma cells. 2018); 1061- 1067
72. Joval, E., Kroeger, P. and Towers, N. Hydroquinone: the toxic compound of Agaricus hondensis. Planta medica. 1996; 62(02); 1015-105
73. Huang HC, Wang HF, Yih KH, Chang LZ, Chang TM. Dual bioactivities of essential oil extracted from the leaves of Artemisia argyi as an anti-melanogenic versus anti-oxidant agent and chemical composition analysis by GC/MS. International Journal of Molecular Sciences. Nov 2012; 13(11); 14679-97.
74. Suhas G. Kshirsagar and Rammoham V. Rao. Anti-viral and Immunomodulation Effects of Artemisia Medicina. Feb 2021; 57(3); 217; 27.
75. Yung-Sheng Lin, Hui-Ju Chen, Jung-Ping Huang, Pei-Chi Lee, Ching-Ru Tsai, Tzu-Fang Hsu, Wen-Ying Huang. "Kinetics of Tyrosinase Inhibitory Activity Using Vitis vinifera Leaf Extracts", BioMed Research International. June 2017; 2017; 5
76. Shweta Parihar, Devender Sharma Scholars Academic Journal of Pharmacy A Breif Overview on Vitis vinifera. Dec, 2021; 10 (12); 231-239
77. Dissanayake CY, Moon HH, Yang KM, Lee Y, Han CH. The effects of green tea (Camellia sinensis) flower extract on melanin synthesis in B16-F10 melanoma cells. Korean Journal of Veterinary Research. Jul 2018; 58(2); 65-72.
78. Kim Donghyun, Park Nok Hyun, Hwang Jeong Ah, Kim Jeongkee, Na Yong-Joo Hwang Jae Sung, Lee Chang Seok, Yang Deok-Chun. Camellia sinensis leaf extracts lacking catechins exert depigmentary effects through ERK-dependent, MiTF-mediated tyrosinase down regulation in melan-a cells and a human skin equivalent. Archives of Biological Sciences. 2019; 71(3); 483-488
79. Mahmood T, Akhtar N, Khan BA. The morphology, characteristics, and medicinal properties of Camellia sinensis tea. Journal of Medicinal Plants Research. Oct 2010; 4(19); 2028-33.
80. Gevrenova R, Zengin G, Sinan KI, Yıldıztugay E, Zheleva-Dimitrova D, Picot-Allain C, Mahomoodally MF, Imran M, Dall’Acqua S. UHPLC-MS Characterization and biological insights of different solvent extracts of two Achillea species (A. aleppica and A. santolinoides) from Turkey. Antioxidants. Jul 2021; 10(8); 1180
81. Rolnik A, Olas B. The plants of the Asteraceae family as agents in the protection of human health. International Journal of Molecular Sciences. Mar 2021; 22(6); 3009.
82. S Bisen P, Emerald M. Nutritional and therapeutic potential of garlic and onion (Allium sp.). Current Nutrition and Food Science. Aug 2016; 12(3); 190-9.
83. Gabriele Rocchetti, Leilei Zhang, Serena Bocchi, Gianluca Giuberti, Gunes Ak, Fevzi Elbasan, Evren Yıldıztugay, Ramazan Ceylan, Marie Carene Nancy Picot-Allain, Mohamad Fawzi Mahomoodally, Luigi Lucini, Gokhan Zengin, The functional potential of nine Allium species related to their untargeted phytochemical characterization, antioxidant capacity and enzyme inhibitory ability. Food Chemistry. 2022;368
84. Sirat HM. Molecular Diversity from Selected Zingiberaceae. In The Open Conference Proceedings Journal. Mar 2013; 4(1).
85. Malabadi RB. In vitro propagation of spiral ginger [Costus speciosus (Koen.) Sm.]. Indian Journal of Genetics and Plant Breeding. Aug, 2002; 62(03); 277-8.
86. Wu LC, Lin CL, Peng CC, Huang TL, Tsai TH, Kuan YE, Chung YC. Development from Jasminum sambac flower extracts of products with floral fragrance and multiple physiological activities. Evidence-Based Complementary and Alternative Medicine. Aug 2021; 2021; 1-2.
87. Tasneem R, Khan HM, Rasool F, Khan KU, Umair M, Esatbeyoglu T, Korma SA. Development of Phytocosmeceutical microemulgel containing flaxseed extract and its in vitro and in vivo characterization. Pharmaceutics. Aug 2022; 14(8); 1656.
88. Al-Snafi AE. Constituents and pharmacology of Narcissus tazetta. IOSR Journal of Pharmacy. 2020; 10(9); 44-53.
89. Adhikari A, Devkota HP, Takano A, Masuda K, Nakane T, Basnet P, Skalko‐Basnet N. Screening of Nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition. International Journal of Cosmetic Science. Oct 2008; 30(5); 353-60.
90. Aktar N, Haji Muhammad Shoaib Khan, Shoaib Ashraf, Imran Shair Mohammad, and Atif Ali. Skin depigmentation activity of Crocus sativus extract cream. Tropical Journal of Pharmaceutical Research. 11(2014); 1803-1808.
91. Berman, Judit, Yanmin Sheng, Lourdes Gómez Gómez, Tania Veiga, Xiuzhen Ni, Gemma Farré, Teresa Capell et al. “Red anthocyanins and yellow carotenoids form the color of orange-flower gentian (Gentianalutea L. var. aurantiaca). 2016; 9 (2016)
92. Kurt-Celep İ, Zengin G, Sinan KI, Ak G, Elbasan F, Yıldıztugay E, Maggi F, Caprioli G, Angeloni S, Sharmeen JB, Mahomoodally MF. Comprehensive evaluation of two Astragalus species (A. campylosema and A. hirsutus) based on biological, toxicological properties and chemical profiling. Food and Chemical Toxicology. Aug 2021; 154:112330; 1-12
93. Khan, Mahmud Tareq Hassan, M. Iqbal Choudhary, Reyhan P. Mamedova, Manzura A. Agzamova, Mukhlis N. Sultankhodzhaev, and Mahamed I. Isaev. Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure–activity relationships. Bioorganic and Medicinal Chemistry. 2006; 17 (2006): 6085-6088
94. Liu B, Xie Y, Wu Z. Astragaloside IV enhances melanogenesis via the AhR-dependent AKT/GSK-3β/β-Catenin pathway in normal human epidermal melanocytes. Evidence-Based Complementary and Alternative Medicine. Dec, 2020; 2020; 1-11.
95. Shin, K. S., H. N. Murthy, J. W. Heo, and K. Y. Paek. Induction of betalain pigmentation in hairy roots of red beet under different radiation sources. Biologiaplantarum. July 2003; 47; 149-152
96. El Gamal AA, AlSaid MS, Raish M, Al-Sohaibani M, Al-Massarani SM, Ahmad A, Hefnawy M, Al-Yahya M, Basoudan OA, Rafatullah S. Beetroot (Beta vulgaris L.) extract ameliorates gentamicin-induced nephrotoxicity associated oxidative stress, inflammation, and apoptosis in rodent model. Mediators of Inflammation. Jan 2014; 2014; 1-12.
97. Lopez‐Nieves, Samuel, Ya Yang, Alfonso Timoneda, Minmin Wang, Tao Feng, Stephen A. Smith, Samuel F. Brockington, and Hiroshi A. Maeda. Relaxation of tyrosine pathway regulation underlies the evolution of betalain pigmentation in Caryophyllales. New Phytologist. 2018; 2(2018); 896-908.
98. Hwang, Eun-Young, Dong-Hee Kim, Jo-Young Hwang, Hui-Jeong Kim, Tae-Soon Park, In-Sun Lee, and Jun-Ho Son. A study on the depigmenting effect of Carthamustinctorius seed, Cyperusrotundus and Schizonepetatenuifolia extracts. Korean Journal of Food Science and Technology. 2012; 1(2012); 76-81.
99. Lou, Li-Li, Sen Liu, Zhi-Yang Yan, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang, and Shao-Jiang Song. Tetrahydro-β-Carboline alkaloids from Carthamustinctorius L. with tyrosinase inhibitory activity. Phytochemistry letters 22 (2017); 107-112.
100. Madadi, M., S. Ghafari, M. Jahandideh, and Z. Hesari. Preparation of a topical herbal formulation for hyperpigmentation. Research Journal of Pharmacognosy Nov, 2017; 4; 58-58.
101. Aylanc, Volkan, Bulent Eskin, GokhanZengin, Mehmet Dursun, and Yavuz Selim Cakmak. In vitro studies on different extracts of fenugreek (Trigonellaspruneriana BOISS.): Phytochemical profile, antioxidant activity, and enzyme inhibition potential. Journal of Food Biochemistry. 2022; 44(11); 1-10
102. Tumen, Ibrahim, FatmaSezerSenol, and Ilkay Erdogan Orhan. Inhibitory potential of the leaves and berries of Myrtuscommunis L.(myrtle) against enzymes linked to neurodegenerative diseases and their antioxidant actions. International Journal of Food Sciences and Nutrition. 2012; 63(4); 387-392.
103. Dastagir, G., and Rizvi, M. A. Glycyrrhizaglabra L. (Liquorice). Pakistan Journal of Pharmaceutical Sciences. 2016; 29(5).
104. Parvaiz, M., Hussain, K., Khalid, S., Hussnain, N., Iram, N., Hussain, Z., and Ali, M. A. A Review: Medicinal importance of Glycyrrhizaglabra L. (Fabaceae family). Global J Pharmacol. 2014; 8(1); 8-13.
105. Kandhari, Sanjeev, et al. Expert opinion on current trends in hyperpigmentation Management: Indian perspective. Int. J. Res. 2022; 8 (1); 142 -151
106. Rathee, Prity, et al. Skin hyperpigmentation and its treatment with herbs: An Alternative method. Future Journal of Pharmaceutical Sciences. 2021; 7(132); 1-14.
107. Gauri, B., Neha, J., andFarhat, D. Aloe vera: a valuable multifunctional cosmetic Ingredient. International Journal of Medicinal and Aromatic Plants. 2011; 1(3), 338-341
108. Arring, N. M., Millstine, D., Marks, L. A., and Nail, L. M. Ginseng as a treatment for Fatigue: a systematic review. The Journal of Alternative and Complementary Medicine. 2018; 24(7): 624-633.
109. Kiefer, David, and Traci Pantuso. “Panax ginseng.” American Family Physician. 2003; 68(8): 1539-1542.
110. LEE, Dae-Young, et al. The potential of minor ginsenosides isolated from the leaves of Panax Ginseng as inhibitors of melanogenesis. International Journal of Molecular Sciences. 2015; 16.(1); 1677-1690.
111. LIU, Jianzeng, et al. Salicylic acid in ginseng root alleviates skin hyperpigmentation disorders By inhibiting melanogenesis and melanosome transport. European Journal of Pharmacology. 2021; 910; 174458
112. KIM, Kwangmi. Effect of ginseng and ginsenosides on melanogenesis and their mechanism of action. Journal of Ginseng Research. 2015; 39(1); 1-6.
113. Benjamin, J., Muir, T., Briggs, K., and Pentland, B. A case of cerebral haemorrhage Can Ginkgo biloba be implicated?. Postgraduate Medical Journal. 2001; 77(904); 112-113.
114. Jager M, Hassanin A, Manuel M, Guyader H L, Deutsch J. MADS-box genes In Ginkgo biloba and the evolution of the AGAMOUS family. Molecular Biology and Evolution. 2003; 20(5); 842-854.
115. Schmutterer, H. Properties and potential of natural pesticides from the neem tree, Azadirachta indica. Annual Review of Entomology. 1990; 35(1); 271-297.
116. Songtavisin, T., Pratoomthai, B., Gangnonngiw, W., andNaowaboot, J. Azadirachta Indica (Neem) Water Leaf Extract Inhibits Melanin Production and Tyrosinase Activity inB16F10 Melanoma Cells. Pharmacognosy Journal. 2021; 13(4).
117. Renuhadevi, M., Ahilan, B., Rajagopalsamy, C. B. T., Jeevagan, I. J. M. A., andPrabu, E. Nutraceuticals in Aqua Feed. Journal of Aquaculture in the Tropics. 2017; 32(3/4): 293-303.
118. Labban L. Medicinal and pharmacological properties of Turmeric (Curcuma longa): A Review. Int J Pharm Biomed Sci. 2014; 5(1); 17-23
119. Goenka, S., Nagabhushanam, K., Majeed, M., and Simon, S. R. Calebin-A, a Curcuminoid analog inhibits α-MSH-induced melanogenesis in B16F10 mouse melanoma cells. Cosmetics. 2019; 6(3); 51.
120. Krueger, R. R., andShaner, D. L. Germination and establishment of prostrate spurge (Euphorbia supina). Weed Science. 1982; 30(3); 286-290
121. Rahman, A. H. M. M., andAkter, M. Taxonomy and medicinal uses of Euphorbiaceae (Spurge) family of Rajshahi, Bangladesh. Research in Plant Sciences. 2013; 1(3); 74-80.
122. Kang, S. H., Jeon, Y. D., Cha, J. Y., Hwang, S. W., Lee, H. Y., Park, M., Lee, Y. M. Antioxidant and skin-whitening effects of aerial part of Euphorbia supinaRaf. Extract. BMC Complementary and Alternative Medicine; 2018; 18(1); 1-8.
123. Yogiraj, V., Goyal, P. K., Chauhan, C. S., Goyal, A., and Vyas, B. Carica papaya Linn: An overview. International Journal of Herbal Medicine. 2014; 2(5); 01-08.
124. Fakeye, T. O., Oladipupo, T., Showande, O, Ogunremi, Y. Effects of Coadministration of extract of Carica papaya Linn (family Cariaceae) on activity of two oral Hypoglycemic agents. Tropical Journal of Pharmaceutical Research. 2007; 6(1); 671-678.
125. Eleazu, C. O., Eleazu, K. C., Awa, E., andChukwuma, S. C. Comparative study of the phytochemical composition of the leaves of five Nigerian medicinal plants. Journal of Biotechnology and Pharmaceutical Research. 2012; 3(2); 42-46.
126. Kumari, M., Radha, Kumar, M., Zhang, B., Amarowicz, R., Puri S, Lorenzo, J. M. Acacia catechu (Lf) Willd: A review on bioactive compounds and their health Promoting functionalities. Plants. 2022; 11(22); 3091
127. Patil KS and Samant SS. Formulation and evaluation of topical polyherbal gel containing Cocculus hirsutus and Tridax procumbens. Int J Pharm Sci and Res. 2023; 14(9); 4560-66.
128. Sheetal S Samant, Vijay A Jagtap, Prajakt Kalangutkar, Raghunath Morye, Akshaya Gadekar, Riddhi Rane and Samidha Desai. Phytochemistry and therapeutic uses of Albizia lebbeck. Sept, 2023; 11(5); 22