Author(s):
Kamel Mokhnache, Ahlem Karbab, EL-Khamsa Soltani, Soraya Madoui, Hanane Khither, Noureddine Charef, Lekhmici Arrar
Email(s):
kamelmokhnache@yahoo.com
DOI:
10.5958/2321-5844.2020.00004.7 
Address:
Kamel Mokhnache*, Ahlem Karbab, EL-Khamsa Soltani, Soraya Madoui, Hanane Khither, Noureddine Charef, Lekhmici Arrar
Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
*Corresponding Author
Published In:
Volume - 11,
Issue - 1,
Year - 2020
ABSTRACT:
A new isatin-hydrazone (IH) was selected for theoretical and experimental studies. The HOMO and LUMO energies were investigated using density functional theory (DFT) via B3LYP/6-31G (d,p), skin sensitization prediction was carried out using Pred Skin software program. The results demonstrate the reactivity of IH with Energy gap (?) of 0.0579 a.u, low sensitizer effect towards human skin with probability of 60 %, and an excellent topical anti-inflammatory effect against xylen-induced ear odema in mice model with inhibition percentages of 81.48%.
Cite this article:
Kamel Mokhnache, Ahlem Karbab, EL-Khamsa Soltani, Soraya Madoui, Hanane Khither, Noureddine Charef, Lekhmici Arrar. Experimental and Computational methods for skin sensitization evaluation of isatin-hydrazone. Research J. Topical and Cosmetic Sci. 2020; 11(1):15-19. doi: 10.5958/2321-5844.2020.00004.7
Cite(Electronic):
Kamel Mokhnache, Ahlem Karbab, EL-Khamsa Soltani, Soraya Madoui, Hanane Khither, Noureddine Charef, Lekhmici Arrar. Experimental and Computational methods for skin sensitization evaluation of isatin-hydrazone. Research J. Topical and Cosmetic Sci. 2020; 11(1):15-19. doi: 10.5958/2321-5844.2020.00004.7 Available on: https://rjtcsonline.com/AbstractView.aspx?PID=2020-11-1-4
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