Author(s):
Sanket Mhaske, Komal Mahadik, Tejal Meghawale, Pravina Kajwe, Auf Arai
Email(s):
sanket.mhaske43@gmail.com , mahadikkomal38@gmail.com , tejalmeghawale18@gmail.com , pravinakajwe@gmail.com , aufarai11@gmail.com.
DOI:
10.52711/2321-5844.2026.00004 
Address:
Sanket Mhaske*, Komal Mahadik, Tejal Meghawale, Pravina Kajwe, Auf Arai
B.K. Patil Institute of Pharmacy, Sector 17, Taloja Phase - 2, Navi Mumbai – 410208.
*Corresponding Author
Published In:
Volume - 17,
Issue - 1,
Year - 2026
ABSTRACT:
The present research involves the formulation and evaluation of a polyherbal anti-acne gel incorporating dual gelling agents—Sodium Alginate and Carboxymethyl Cellulose (CMC). The formulation integrates five medicinally significant herbal ingredients: Azadirachta indica (Neem), Ocimum sanctum (Tulsi), Aloe barbadensis (Aloe Vera), Curcuma longa (Turmeric), and Melaleuca alternifolia (Tea Tree Oil), selected for their established anti-inflammatory, antimicrobial, antioxidant, and wound-healing properties. Herbal extracts were obtained using optimized extraction techniques such as cold infusion, decoction, and hot infusion to preserve phytoconstituents. The gel was formulated by combining the active extracts with the dual gelling system and evaluated for various parameters including pH, viscosity, spreadability, drug content, microbial load, and skin irritation potential. The developed gel exhibited ideal physicochemical characteristics with a pH of 5.84, good spreadability, and uniform drug content (97.4%). Microbial testing confirmed the product's safety, and no irritation was observed during patch testing, indicating its dermatological compatibility. The study concludes that the dual-gelled polyherbal formulation is a stable, safe, and effective topical preparation for acne treatment, offering a natural alternative to conventional therapies.
Cite this article:
Sanket Mhaske, Komal Mahadik, Tejal Meghawale, Pravina Kajwe, Auf Arai. Formulation and Evaluation of a Polyherbal Anti Acne Gel: Incorporating Dual Gelling Agent. Research Journal of Topical and Cosmetic Sciences. 2026; 17(1):15-0. doi: 10.52711/2321-5844.2026.00004
Cite(Electronic):
Sanket Mhaske, Komal Mahadik, Tejal Meghawale, Pravina Kajwe, Auf Arai. Formulation and Evaluation of a Polyherbal Anti Acne Gel: Incorporating Dual Gelling Agent. Research Journal of Topical and Cosmetic Sciences. 2026; 17(1):15-0. doi: 10.52711/2321-5844.2026.00004 Available on: https://rjtcsonline.com/AbstractView.aspx?PID=2026-17-1-4
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