Author(s): Vandana Gupta, Jaya Singh

Email(s): jayasingh.2902@gmail.com , Vandugpt69@gmail.com

DOI: 10.52711/2321-5844.2021.00012   

Address: Vandana Gupta, Jaya Singh1*
Innovative College of Pharmacy, Greater Noida, Uttar Pradesh - 201308.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2021


ABSTRACT:
Gastric emptying is a complicated process in the human body because it is very inconstant, resulting in ambiguous in vivo drug delivery system efficacy. To combat this variability, scientists have been working on developing a regulated medication delivery system with a long gastric residence period. This review article on gastroretentive drug delivery systems (GRDDS) focuses on numerous gastroretentive approaches that have recently emerged as a leading methodology in the field of site-specific orally administered controlled release drug administration. Gastroretentive medicines come in a variety of forms on the market, including tablets, granules, capsules, floating microspheres, laminated films, and powders. Floating microspheres are currently garnering more attention than previous techniques because of their benefits, which include more consistent drug absorption and a lower risk of local discomfort. The primary goal of this method is to increase gastric retention time in the GIT, which is defined as more than 12 hours in the stomach with an absorption window in the upper small intestine. Longer stomach retention improves bioavailability, reduces drug waste, and boosts solubility for medications that are less soluble in a high pH environment. The medicines are released into the stomach for a long time and consistently thanks to the floating microsphere systems. The current study compiles the most recent research on the techniques of production, characterization, and numerous aspects that impact the performance of floating microspheres for oral administration.


Cite this article:
Vandana Gupta, Jaya Singh. A Novel Drug Delivery System: Floating Microspheres in the Development of Gastroretentive Drug Delivery System. Research Journal of Topical and Cosmetic Sciences. 2021; 12(2):86-2. doi: 10.52711/2321-5844.2021.00012

Cite(Electronic):
Vandana Gupta, Jaya Singh. A Novel Drug Delivery System: Floating Microspheres in the Development of Gastroretentive Drug Delivery System. Research Journal of Topical and Cosmetic Sciences. 2021; 12(2):86-2. doi: 10.52711/2321-5844.2021.00012   Available on: https://rjtcsonline.com/AbstractView.aspx?PID=2021-12-2-3


REFERENCE:
1.    Anuradha A. Birajdar, Madhuri T. Deshmukh, Rajkumar V. Shete, A Review on Gastro-Retentive Floating Microspheres. Journal of Drug Delivery & Therapeutics. 2021; 11(1-s):131-138
2.    Lalit Kumar1 Abhishek Sharma, Gastro Retentive Floating Microsphere, A Review Journal of Pharmaceutical Science and  Bioscientific Research 2019. 9 (2):142-148
3.    Deb J., Venkateswarlu B.S., Ghosh A, Choudhuri, Paul P, Faizi M, Asian Journal of Biomedical and Pharmaceutical Sciences 1 (2) 2011, 11-19
4.    Fmith Celvia Miranda, Krishnananda Kamath K., and A. R. Shabaraya , Floating Microspheres: A Review World Journal of Pharmacy and Pharmaceutical Sciences 2019;8(7)
5.    Sharma AR and Afroz Khan: Gastroretentive Drug Delivery System, An approach to enhance Gastric retention for prolonged drug release. Int J Pharm Sci Res 2014; 5(4): 1095-06.    
6.    Aniket Uttam Pund , Raosaheb Sopanrao Shendge , Ajinkya Kailas Pote , Current Approaches on Gastroretentive Drug Delivery systems  Journal of Drug Delivery & Therapeutics. 2020; 10(1):139-146
7.    Nisha Sharma, Neha Purwar, and Prakash Chandra Gupta, Microspheres as drug carriers for controlled drug delivery: A Review. IJPSR, 2015; 6(11): 4579-4587
8.    Mishra A, Rathore S, Marothia D, Chauhan CS (2018), Formulation and Evaluation of Floating Microspheres of an Anti-Diabetic Agent. Int J Drug Dev & Res 10: 7-11
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