K. Chaitanya Prasad, Somesetty Pavani, Ramya Sri S.
K. Chaitanya Prasad1*, Somesetty Pavani1, Ramya Sri S.2
1Department of Pharmaceutics, Samskruti College of Pharmacy, Affiliated to JNTUH University, Hyderabad 501301, Telangana, India.
2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad – 500 007, Telangana, India.
Volume - 13,
Issue - 2,
Year - 2022
The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Cyproheptadine with different ratios of polymeric systems by the Solvent evaporation technique by using Dibutyl phthalate to the polymer weight, incorporated as plasticizer. Dimethylsulphoxide were used to enhance the transdermal permeation of Cyproheptadine. The physicochemical compatibility of the drug and the polymers studied by infrared spectroscopy suggested absence of any incompatibility. Formulated transdermal patches were physically evaluated with regard to thickness, weight variation, drug content, flatness, tensile strength and folding endurance. In-vitro drug studies of formulations were performed by using Franz diffusion cells. The results followed the release profile of Cyproheptadine followed mixed peppas release kinetics. However, the release profile of the optimized formulation F3 (98.51% at 12hr) indicated that the permeation of the drug from the patches was governed by a diffusion mechanism.
Cite this article:
K. Chaitanya Prasad, Somesetty Pavani, Ramya Sri S. Formulation and Characterization of Transdermal Patches for Controlled Delivery of Cyproheptadine. Research Journal of Topical and Cosmetic Sciences. 2022; 13(2):71-5. doi: 10.52711/2321-5844.2022.00012
K. Chaitanya Prasad, Somesetty Pavani, Ramya Sri S. Formulation and Characterization of Transdermal Patches for Controlled Delivery of Cyproheptadine. Research Journal of Topical and Cosmetic Sciences. 2022; 13(2):71-5. doi: 10.52711/2321-5844.2022.00012 Available on: https://rjtcsonline.com/AbstractView.aspx?PID=2022-13-2-4
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