Preparation and Evaluation of Semi-Synthetic Antidandruff Shampoo

 

Atul Wakshe, Ajinkya Thorat, Shaharukh Tamboli,

Shubhangi Thorat, Manisha Manik Murgude*

Rajarambapu College of Pharmacy, Kasegaon.

*Corresponding Author E-mail: manisham74@gmail.com

 

ABSTRACT:

Shampooing is the most common form of hair treatment to remove dirt, grease and debris from the hair, scalp and other parts of body without damaging the natural gloss of hair and to keep the hair fragrant, lustrous, soft and manageable. The shampoo is prepared by using two Antidandruff agents such as Potato and Coriander leaves extract. The other ingredients used are sodium lauryl sulphate as surfactant, urea as solubilizing agent, sodium EDTA as chelating agent, guar gum as foam stabilizer and thickening agent, tween 80 as well as distilled water is used as vehicle. It was evaluated for various tests and the ranges were in acceptable limits. The pH range was 6.4 to 6.8, physical appearance was yellowish green. The percentage (%) of solid contents ranges from 22.9 to 26.5, viscosity was in the range of 1000 to 1600, and foam value 150mm to 175mm. The anti-microbial activity was done by using staphylococcus aureus, the zone of inhibition by 1% solution using Potato: coriander Leaves extract in the ratio of 1:2 have shown 3.1mm of inhibitory action. The present research emphasizes about the preparation & evaluation of Semi-Synthetic antidandruff cosmetic shampoo.

 

KEYWORDS: Potato, coriander leaves extract, anti-dandruff, Semi-Synthetic.

 

 

 

INTRODUCTION:

Shampooing is the most common form of hair treatment to remove dirt, grease and debris from the hair, scalp and other parts of body without damaging the natural gloss of hair and to keep the hair fragrant, lustrous, soft and manageable. “Used to treat or prevent dandruff is called as Antidandruff shampoo”

 

Potato are rich in potassium, vitamin c, and iron. That is essential for hair growth. Potatoes contain high amount of minerals like zinc, copper, calcium, etc which are very beneficial for healthy and dandruff free scalp. Here is a simple way to use potato to get rid of dandruff. Dryness in the scalp can causes dandruff, which can lead to hair thinning and breakage. Potato juice is potent solution for the dryness for healthy growth.  

 

Synonym:

Coriander fruits.

 

Biological source:

These are the fully dried ripe fruit of the plant known as Coriandrum sativum Linn

 

Family:

Umbelliferae.

Coriander is rich in protein, iron, fibers, carbohydrate and many more

 

Make the coriander juice by grinding the chopped coriander leave which help in hair growth

 

It also give hair restoration

A shampoo is said to be ideal when it (i) effectively and completely remove the dust particles and excessive sebum from the scalp and hair, (ii) easily removed when rinsed with water, (iii) leave the hair non dry, soft and manageable, (iv) impart a pleasant fragrance to the hair and (v) cause no side effects or irritation to skin or hair The rationale of the study include, herbs is been used for thousands of year due to its medicinal properties. Body starts to get cleansed and gets purify itself when herbs are taken. These natural botanicals may be used in their crude form or they may be extracted, purified or derivatized to render them more suitable for cosmetic purposes. some of the plants which are reported to have beneficial effects on hair and are commonly used in anti-dandruff shampoos. Hence in the present study, we attempt to find to formulate an efficient semi-synthetic shampoo with variety of plant ingredients.

MATERIAL AND METHODS:

Collection of plants:

The fresh potato crushed in grinder then juice was collected. Coriander leaves were obtained from the local markets. These leaves kept for shade drying then made into powdered form and stored in air tight containers until it is further used in the formulation.

 

 

 

Table No 1

Sr. No

Ingredients (grams)

F1

F2

F3

F4

Role

1.   

Potato Juice

0.50

1

2

2.50

Antidandruff Agent

2.   

Coriander Leaves extract

1

2

4

5

Antidandruff Agents

3.   

Sodium Lauryl Sulphate

3

3

3

3

Surfactant

4.   

Urea

0.5

0.5

0.5

0.5

Solubilizing Agent

5.   

Citric Acid

0.25

0.25

0.25

0.25

Sequestering agent

6.   

Sodium EDTA

0.25

0.25

0.25

0.25

Chelating agent

7.   

Guar Gum

0.25

0.25

0.25

0.25

Thickening agent

8.   

Methyl paraben

0.5

0.5

0.5

0.5

preservative

9.   

Tween 80

0.5

0.5

0.5

0.5

Vehicle

10.

Distilled water(ml)

Upto 50ml

Upto 50ml

Upto 50ml

Upto 50ml

Vehicle

 

 

Extraction Process:

The Coriandrum sativum contain essential oil, tannins, terpenoids, reducing sugars, alkaloids, phenolics, flavonoids, fatty acids, sterols and glycosides. Extraction of Coriandrum sativum was done by using the following method. The air-dried samples of Coriandrum sativum were powdered and passed through 20 mesh sieve. The sieved material (50 g) was extracted with 200 ml solvent of alcohol and water (50:50) at the temperature of 60-65oC for 24-48 hrs in a Soxhlet apparatus. The material was filtered and marc was further refluxed. The extract concentrated and finally the material was air-dried after removal of the above solvents. Extraction was done as per the Ayurvedic Pharmacopoeia of India.

 

Preparation of Antidandruff Shampoo:

The antidandruff shampoo was formulated using simple mixing process. Formulations were made by using two antidandruff agents such as Potato and Coriander leaves extract. The other ingredients used are sodium lauryl sulphate as surfactant, urea as olubilizing agent, citric acid as sequestering agent, sodium EDTA as chelating agent, guar gum as foam stabilizing agent and thickening agent, methyl paraben used as preservatives, tween 80 & distilled water as vehicle.

 

Fig. No.1

 

Evaluation of Prepared Antidandruff Shampoo:

Physical appearance/Visual inspection:

The formulations prepared were evaluated in terms of their clarity, foam producing ability and fluidity.

 

Fig. No.2

 

Determination of pH:

The pH of 10% shampoo solution in distilled water was determined at room temperature 25o C.

 

Fig. No.3

Determine percent of solid contents:

A clean dry evaporating dish was weighed and added 4 grams of shampoo to the evaporating dish. The dish and shampoo was weighed. The exact weight of the shampoo was calculated (only solids) and evaporating dish with shampoo was placed on hot plate until the liquid portion was evaporated. The weight of the shampoo (only solids) after drying was calculated.

 

Table No.2: Evaluation of Formulation for Physical Appearance, pH and Solids

Sr. No

Formulation

Physical Appearance

PH

Solid (%)

1

F1

Yellowish green

6.8

26.5

2

F2

Yellowish green

6.5

23.4

3

F3

Slightly green

6.7

24.8

4

F4

green

6.4

22.9

 

Rheological evaluation:

 The viscosity of the shampoos was determined by using Brookfield viscometer by setting different speeds from 0.3 to 10 rpm. The viscocity of the shampoos was measured by T95. The temperature and sample container’s size was kept constant during the study.

 

Fig.No.4

 

Foaming ability and Foam stability:

Cylinder shake method was used for determining foaming ability. 50ml of 1% shampoo solution was put into a 250ml graduated cylinder and is shaken for 10 times. The total volumes of foam contents after 1minute shaking were recorded. The foam value was calculated immediately after shaking the volume of foam at 1 minute intervals for 4 minutes were recorded.

 

 

 

 

Table No.3:

Table-Evaluation for viscosity & foam value of formulation.

Sr. No

Formulation

Viscosity

Foam Volume (ml)

1

F1

1200

173

2

F2

1400

142

3

F3

1600

134

4

F4

1000

157

 

Anti-microbial activity against Staphylococcus aureus:

The prepared antidandruff shampoo formulations F1 to F4 were subjected to antimicrobial activity by cup plate method using the agar medium. 1% antidandruff shampoo was used to study this antimicrobial activity. The petriplates were then sealed using para film and incubated at 37o C for 24 hrs. The zone of inhibition was observed successfully for formulation F1 than other formulations.

 

Fig. No. 5

 

Fig. No. 6

 

Fig. No. 7

 

Table No. 4: Evaluation of formulations for Zone of Inhibition

Sr. No

Formulation

Concentration (gm) Potato Juice

Concentration (gm) Coriander Leaves Juice

Zone of Inhibition (mm)

Staphylococcus aureus

1

F1

0.50

1

3.1

2

F2

1

2

2.7

3

F3

2

4

2.2

4

F4

2.50

5

2.6

 

Fig. No.8

 

RESULTS AND DISCUSSION:

The aim of the present work is to prepare Antidandruff shampoo by using two antidandruff agents such as Potato and Coriander leaves Juices by various combinations. The prepared Antidandruff shampoo was evaluated for physical appearance/visual inspection, determination if pH, determine % of solid contents, rheological evaluation, foam ability and antimicrobial activity.

 

Physical appearance/visual inspection:

The formulations prepared were appeared in yellowish green colour.

 

Determination of pH:

The pH of 10% shampoo solution in distilled water was determined at room temperature 25oC and the range of pH was found to be 6.4 to 6.8.

 

Determine percent of solid contents:

The weight of the shampoo (only solids) after drying was calculated for all the formulations and the range was found to be 22.9% to 26.5%.

 

Rheological evaluation:

The viscosity of the shampoo was determined by using Brookfield Viscometer by setting different spindle speeds from 0.3 to 10rpm and the range of cps obtained was 1000 to 1600.

 

Foaming ability:

Cylinder shake method was used for determining foaming ability. 50ml of 1% shampoo solution was put into a 250ml graduated cylinder and covered the cylinder with hand and shaken for 10 times and the range of values obtained was found to be 150-175.

Antimicrobial activity against Staphylococcus aureus:

The prepared antidandruff shampoo formulations F1 to F4 were subjected to antimicrobial activity by using cup-plate method using agar medium. 1% antidandruff shampoo was used to study this antimicrobial activity. The zone of inhibition was observed successfully for formulation F1 than other formulations.

 

CONCLUSION:

In the present work, efforts have been made to prepare and evaluate Antidandruff shampoo by using two antidandruff agents such as potato and Coriander leaves extracts by various combinations. Zone of inhibition for F1 obtained was best compared to other formulations against Staphylococcus aureus after incubating for 24 hrs. It may have fair antidandruff activity efficiency. Hence the formulation F1 has met the objectives of the present study which may hold promise for further studies.

 

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Received on 21.06.2019                    Accepted on 16.08.2019

©A&V Publications all right reserved

Research J. Topical and Cosmetic Sci. 10(2): July- Dec. 2019 page 57-60.

DOI: 10.5958/2321-5844.2019.00012.8