Aquasomes are like "bodies of water" and their water as properties protect and preserve fragile biological molecules and this property of maintaining conformational integrity and high degree of surface exposure is exploited for targeting bio-active molecules such as peptide and protein hormones, enzymes, antigens and genes to specific sites. These three layered structures are self-assembled by ionic and non-covalent bonds. These carbohydrates stabilize ceramic nanoparticles and are known as "aquasomes." The pharmacologically active molecule added to the carbohydrate surface of preformed nanoparticles through copolymerisation, diffusion or adsorption. The discovery of aquasomes includes a principle of microbiology, food chemistry, biophysics and many discoveries including solid phase synthesis, supramolecular chemistry, change of molecular shape and self-assembly. Principal of “self assembly of macromolecule” is covered by three physiochemical processes that interact with charged group, the interaction of charged group promotes the long-range approach of the charging group of self-assembly sub-units also plays a role in stabilizing tertiary structures of folded protein.
Cite this article:
Akshay R. Yadav, Shrinivas K. Mohite. Aquasomes as a Self Assembling Nanobiopharmaceutical Carrier System for Bio-Active Molecules. Research J. Topical and Cosmetic Sci. 2020; 11(2):89-94. doi: 10.5958/2321-5844.2020.00016.3
1. Wani S, Yerawar A. Aquasomes: A novel nanocarrier for drug delivery. Chem Inform. 2011; 42(46): 58-64.
2. Gholap AD, Borude SS, Mahajan AM, Gholap MAD. Aquasomes: A potential drug delivery carrier. Pharmacol Online. 2011; 3: 230-237.
3. Sirikonda AK, Kumar BV, Soma Sekhar A, Gopi M, Babu HS, Rao GS. Aquasomes: A Review. Chem Inform. 2014; 45(14): 25-29.
4. Rathore P, Duggal S, Swami G. Aquasomes: a promising nanobiopharmaceutical drug delivery system for proteins and peptides. Chem Inform. 2013; 44(17): 18-25.
5. Mesariya S, Joshi K, Jain H, Upadhyay U. Aquasomes—A Self‐Assembled Nanotechnology System. Chem Inform. 2012; 43(30): 69-72.
6. Prausnitz MR. Microneedles for Transdermal Drug Delivery. Adv Drug Deliver. Rev. 2004; 56: 581-587.
7. Pillai O, Nair V, Panchagnula R, Transdermal Iontophoresis of Insulin: Influence of Chemical Enhancers. Int J Pharm. 2004; 269: 109-120.
8. Paul W, Sharma CP. Porous Hydroxyapatite Nanoparticles for Intestinal Delivery of Insulin. Trend Biomat Ar Org. 2001; 14: 37-38.
9. Rawat M, Singh D, Saraf S, Saraf S. Development and In vitro Evaluation of Alginate Gel-Encapsulated, ChitosanCoated Ceramic Nanocores for Oral Delivery of Enzyme. Drug Develop Ind Pharm. 2008; 34: 181-188.
10. Patil S, Pancholli SS, Agrawal S, Agrawal GP. Surface-modified Mesoporous Ceramics as Delivery Vehicle for Haemoglobin. Drug Del. 2004, 11, 193-199.
11. Kossovsky N, Gelman A, Hnatyszyn HJ, Rajguru S, Garrell LR, Torbati S. Surface Modified Diamond Nanoparticles as Antigen Delivery Vehicles. Bioconj Chem. 1995; 6: 507-510.
12. Crowe J. H., Crowe L.M. and Chapman D. Infrared spectroscopic studies on interactions of water and carbohydrate with a biological membrane. Arch. Biochem. Biophys. 1984; 232: 400.
13. Haberland, M.E, Fless, G.M.; Scannu, A.M. and Fogel man, A.M. Malondiaalde hyde de modification of lipoprotein produces avid uptake by human monocytes macrophages. J. boil. chem, 1992; 267: 4143-4159.
14. Dunitz, J.D. The entropic cost of bound water in crystals. biomol sci. 1994; 264-670.
15. Horbett, T.A.; Brash, J.L. proteins at interface; current issues and future prospects in; Proteins at interfaces physiochemical and biological studies ACS Symposium Series. washington: Acs, 1987; 343: 1-33.
16. Israelachvilli, J. N. Intermolecular and surface force New York. Academic press.1985. 15.
17. Cherian, A. and Jain S.K. “Self assembled carbohydrate stabilized ceramic nanoparticles for the parentral drug delivery of insulin” Drug development and industrial pharmacy 2000; 26: 459-463.
18. Jain NK, Umamaheshwari RB. Control and novel drug delivery systems. In: Jain NK, editor. Pharmaceutical product development. CBS Publishers & Distributors, New Delhi. 2006: 419-455.
19. Vyas SP, Goyal AK, Rawat A, Mahor S, Gupta PN, Khatri K, Nanodecoy system: a novel approach to design hepatitis B vaccine for immune potentiation. Int J Pharm 2006; 309: 227-233.
20. Vyas SP, Goyal AK, Khatri K, Mishra N, Mehta A, Vaidya B, et al. Aquasomes-a nanoparticulate approach for the delivery of antigen. Drug Dev Ind Pharm 2008; 34: 1297-1305.
21. Cherian, A. and Jain S.K. Self assembled carbohydrate stabilized ceramic nanoparticles for the parentral drug delivery of insulin. 2000; 15: 459-463.
22. Kossovsky, N; Gelman.A. and Sponsler, E.E. Cross linking encapsulated haemoglobin solid phase supports: lipid enveloped haemoglobin adsorbed to surfacemodified ceramic particles exhibit physiological oxygen lability artif. cells blood sub biotech. 1993; 223: 479-485.