Volume No. :   11

Issue No. :  1

Year :  2020

ISSN Print :  0976-2981

ISSN Online :  2321-5844


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Skin Sensitization Calculation, Topical Anti-Inflammatory effect and DFT study of new Indole-Hydrazone



Address:   Kamel Mokhnache*, Ahlem Karbab, EL-Khamsa Soltani, Soraya Madoui, Hanane Khither, Noureddine Charef, Lekhmici Arrar
Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
*Corresponding Author
DOI No: 10.5958/2321-5844.2020.00004.7

ABSTRACT:
A new indol-hydrazone (IH); N'-[(E)-(5-bromo-1H- indol-3-yl) methylidene] pyridine-4-carbohydrazide was selected for theoretical and experimental studies. Molecular structure proprieties were investigated using density functional theory (DFT) via B3LYP/6-31G (d,p), skin sensitization prediction was carried out using Pred Skin software program. The obtained results demonstrate the reactivity of IH with Energy gap (?) of 0.0579 a.u, low sensitizer effect towards human skin with probability of 60 %, and an excellent topical anti-inflammatory effect against xylen-induced ear odema in mice model with inhibition percentages of 81.48%.
KEYWORDS:
Hydrazone, skin sensitization, Topical, Anti-inflammatory.
Cite:
Kamel Mokhnache, Ahlem Karbab, EL-Khamsa Soltani, Soraya Madoui, Hanane Khither, Noureddine Charef, Lekhmici Arrar. Skin Sensitization Calculation, Topical Anti-Inflammatory effect and DFT study of new Indole-Hydrazone. Research J. Topical and Cosmetic Sci. 2020; 11(1):15-19.
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