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Research Journal of Topical and Cosmetic Sciences
ISSN: 2321-5844(Online), 0976-2981(Print)
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Formulation and Evaluation of Topical Antifungal Gel Containing Itraconazole
Poonam Madhukar Kasar
Kalyani Sundarrao Kale
Dipti Ganesh Phadtare
Poonam Madhukar Kasar*, Kalyani Sundarrao Kale, Dipti Ganesh Phadtare
R.G.S Institute of Pharmacy, Anjaneri, Nashik, Maharashtra India
The present research has been undertaken with the aim to develop a topical gel formulation of Itraconazole. Itraconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral use of Itraconazole is not much recommended as it has many side effects. Commercially Itraconazole topical gel preparation are not available in the market, thus this formulation is made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage. The gel was formulated by changing the polymer ratio. Formulation were evaluated for % yield, spredability, extrudability, washability and viscosity in-vitro drug release study, skin irritation study, stability testing and finally it was concluded that formulation F3 was the best formulation among these formulation.
Itraconazole, Carbopol 934p, HPMC.
Poonam Madhukar Kasar, Kalyani Sundarrao Kale, Dipti Ganesh Phadtare. Formulation and Evaluation of Topical Antifungal Gel Containing Itraconazole. Research J. Topical and Cosmetic Sci. 9(2): July- Dec. 2018 page 49-52.
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