Volume No. :   9

Issue No. :  2

Year :  2018

ISSN Print :  0976-2981

ISSN Online :  2321-5844


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Development and evaluation of Rubia cordifolia gel for treatment of Acne



Address:   Archana Gorle1 *, Swati Patil2
1NCRD’S Sterling Institute of Pharmacy, plot No 93, Sector -19 Seawoods, Nerul (E) , Navi Mumbai- 400706, Maharashtra, India.
2Principal K. M. Kundnani College of Pharmacy, Plot NO. 23, Jote Joy Bldg, Cuffe Parade, Colaba, Mumbai 400 005, India.
*Corresponding Author
DOI No: 10.5958/2321-5844.2018.00008.0

ABSTRACT:
Acne is disorder of pilosebaceous unit, and generally characterized by formation of seborrhea, comedones, inflammatory lesions and presence of bacteria Propionibacterium acnes in the follicular canal and sebum production. Each of these factors provides a potential target for treatment. Propionibacterium acnes are the pharmacological target site of anti-acne drugs. methanolic extract was prepared and evaluated for antioxidant and antibacterial activity The aim of present study was to prepare herbal gel formulation containing methanolic extract of Rubia cordifolia on acne. Topical gel formulation was designed by using methanolic extract of roots and stems of Rubia cordifolia in varied concentrations. The gel was prepared by using carbopol 940(1%w/v), Rubia cordifolia Extract, ethanol, propylene glycol, methyl paraben, propyl paraben, EDTA disodium, tri-ethanolamine and required amount of distilled water The prepared gels were evaluated for physical appearance, pH, drug content, diffusion study, viscosity, antibacterial activity. Thus, it may be concluded that gel formulations were good antibacterial and antioxidant activity can be used in antiacne activity.
KEYWORDS:
Rubia cordifolia, carbopol, Herbal gel, Acne.
Cite:
Archana Gorle, Swati Patil. Development and evaluation of Rubia cordifolia gel for treatment of Acne. Research J. Topical and Cosmetic Sci. 9(2): July- Dec. 2018 page 39-43.
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