Volume No. :   8

Issue No. :  2

Year :  2017

ISSN Print :  0976-2981

ISSN Online :  2321-5844


Registration

Allready Registrered
Click to Login

Polymeric Novel Vesicular Drug Delivery System: An Updated Overview of Microspheres



Address:   Katta. Manogna*, E. Nanda Krishna Reddy, T.N. Shilpa
S V U College of Pharmaceutical Sciences, S V University, Tirupati
*Corresponding Author
DOI No: 10.5958/2321-5844.2017.00008.5

ABSTRACT:
Microspheres are categorized under the vesicular drug delivery system, encapsulated by proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 ┬Ám. The internal structure of the microspheres can vary as a function of the microencapsulation process employed. The encapsulation is carried out by various preparation methods. Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to specific site at a predetermined rate. Drugs can be targeted to specific sites in the body using microspheres. The rate of drug release from the microspheres dictates their therapeutic action. Release is governed by the molecular structure of the drug and the polymer, the resistance of the polymer to degradation, and the surface area along with the porosity of the microspheres. This article aims to provide a comprehensive review of advantages, methods of preparation, mechanism, routes of administration, different types of microspheres based on natural and synthetic biodegradable polymers and application of biodegradable polymeric microspheres.
KEYWORDS:
Microspheres, microencapsulation, polymers, controlled drug delivery, biodegradable
Cite:
Katta. Manogna, E. Nanda Krishna Reddy, T.N. Shilpa. Polymeric Novel Vesicular Drug Delivery System: An Updated Overview of Microspheres. Research J. Topical and Cosmetic Sci. 8(2): July-Dec. 2017 page 64-72.
[View HTML]      [View PDF]



Visitor's No. :   61758