Author(s): Dipti G. Phadtare, Manisha N.Gaika, Smita S. Aher

Email(s): manishagaikar44@gmail.com

DOI: Not Available

Address: Dipti G. Phadtare1* , Manisha N.Gaika2, Smita S. Aher3
1Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, India.
2Department of Quality Assurance Techniques, R.G.Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, India.
3Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2016


ABSTRACT:
The present study was aimed to develop a nanoemulsion based nasal spray of Azelastine hydrochloride for improved bioavailability by circumventing the hepatic first pass metabolism and patient compliance. The aim of the present study was to prepare and evaluate different formulations of Azelastine Hydrochloride in nanoemulsion based using castor oil as oil phase, polysorbate 80 and cremophor RH 40 as surfactant used. Castor oil was selected as oil phase due to it’s good solubilising capacity. The prepared formulations were characterized by pH, Drug content, Viscosity, Stability study etc. pH of all the formulations were found to be within the range between 5-7 and the nasal mucosa can tolerate the above mentioned pH of the formulations. Five different formulations were formulated with various values of oil (0.5-5%), Water (10-50%) and surfactant.The results indicated that the nanoemulsion system studied would be a promising tool for enhancing the nasal delivery of Azelastine hydrochloride.


Cite this article:
Dipti G. Phadtare, Manisha N.Gaika, Smita S. Aher. Formulation and Characterization of Nanoemulsion Based Nasal Spray of Azelastine Hydrochloride. Research J. Topical and Cosmetic Sci. 2016; 7(2): 55-66.


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Research Journal of Topical and Cosmetic Sciences (RJTCS) is an international, peer-reviewed journal, correspondence in the fields of skin and cosmetic research....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2321-5844 


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