Author(s): Rabindra K Nanda, Amol A Kulkarni, Meenal N Ranjane, Poonam N. Ranjane

Email(s): amolk301@rediffmail.com

DOI: Not Available

Address: Rabindra K Nanda*, Amol A Kulkarni, Meenal N Ranjane and Poonam N. Ranjane
Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharahtra, India.
*Corresponding Author

Published In:   Volume - 1,      Issue - 1,     Year - 2010


ABSTRACT:
The present work describes a stability-indicating HPTLC method for analysis of nadifloxacin in topical cream. The separation was carried out on Merck precoated silica gel aluminium plate 60 F254 using Chloroform: Methanol: Ammonia (4.3: 4.3: 1.4 v/v/v) as mobile phase. The densitometric scanning was carried out at 296 nm. Response was found to be linear in the concentration range of 50–300 ng /band with correlation coefficients (r2 = 0.9979). The method was validated as per ICH guidelines. The method was successfully applied for the analysis of drugs in pharmaceutical formulation. Nadifloxacin was subjected to forced degradation by acid, alkali, neutral, oxidation, dry heat, wet heat, sunlight, UV light. The degradation products were well resolved from the pure drug with significantly different RF values.


Cite this article:
Rabindra K Nanda, Amol A Kulkarni, Meenal N Ranjane , Poonam N. Ranjane. A Stability-indicating HPTLC method for estimation of Nadifloxacin in topical cream. Res. J. Topical and Cosmetic Sci. 1(1): Jan. – June 2010 page 25-29.


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DOI: 10.5958/2321-5844 


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